5'-O-DMTr-2'-O-TBDMS-N-Bz-adenosine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

Base Information

Chemical Name:5'-O-DMTr-2'-O-TBDMS-N-Bz-adenosine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt
CAS No.:127553-42-8
Molecular Formula:C₆H₁₅N*C₅₀H₅₃ClN₅O₁₀PSi
Molecular Weight:1079.7
Hs Code.:

Synonyms:5'-O-DMTr-2'-O-TBDMS-N-Bz-adenosine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

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Chemical Property of 5'-O-DMTr-2'-O-TBDMS-N-Bz-adenosine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

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Technology Process of 5'-O-DMTr-2'-O-TBDMS-N-Bz-adenosine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

There total 4 articles about 5'-O-DMTr-2'-O-TBDMS-N-Bz-adenosine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 129681-71-6,81265-93-2
5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine

: 121-44-8
triethylamine

: 15074-54-1
2-chlorophenyl dichlorophosphate

: 127553-42-8
5'-O-DMTr-2'-O-TBDMS-N-Bz-adenosine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

Guidance literature:: 5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine; triethylamine; 2-chlorophenyl dichlorophosphate; With 1,2,4-Triazole; In dichloromethane; for 2.5h; Cooling with ice;

With tetraethylammonium bromide; water; In dichloromethane; for 0.5h;

Reference yield:

: 15715-58-9
triethylamine carbonate

: 129681-71-6,81265-93-2
5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine

: 15074-54-1
2-chlorophenyl dichlorophosphate

: 127553-42-8
5'-O-DMTr-2'-O-TBDMS-N-Bz-adenosine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

Guidance literature:: 2-chlorophenyl dichlorophosphate; With pyridine; In dichloromethane; for 1h; Cooling with ice;

5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine; In dichloromethane; for 2h; Cooling with ice;

triethylamine carbonate; In dichloromethane;
DOI:10.1016/j.tetlet.2012.05.027

Reference yield:

: 5204-74-0
triethylammonium acetate

: 129681-71-6,81265-93-2
5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine

: 15074-54-1
2-chlorophenyl dichlorophosphate

: 127553-42-8
5'-O-DMTr-2'-O-TBDMS-N-Bz-adenosine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt

Guidance literature:: 2-chlorophenyl dichlorophosphate; With 1,2,4-Triazole; triethylamine; In dichloromethane; for 1h; Cooling with ice;

5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine; In dichloromethane; for 2.5h; Cooling with ice;

triethylammonium acetate; In dichloromethane; for 0.5h;