trans-[1,1'-bi(cyclohexane)]-4,4'-dicarbaldehyde

Base Information

Chemical Name:trans-[1,1'-bi(cyclohexane)]-4,4'-dicarbaldehyde
CAS No.:189387-84-6
Molecular Formula:C₁₄H₂₂O₂
Molecular Weight:222.327
Hs Code.:

Synonyms:trans-[1,1'-bi(cyclohexane)]-4,4'-dicarbaldehyde

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Chemical Property of trans-[1,1'-bi(cyclohexane)]-4,4'-dicarbaldehyde

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Technology Process of trans-[1,1'-bi(cyclohexane)]-4,4'-dicarbaldehyde

There total 1 articles about trans-[1,1'-bi(cyclohexane)]-4,4'-dicarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 23391-99-3
4,4'-bicyclohexanone

: 4009-98-7
(methoxymethyl)triphenylphosphonium chloride

: 189387-84-6
trans-[1,1'-bi(cyclohexane)]-4,4'-dicarbaldehyde

Guidance literature:: (methoxymethyl)triphenylphosphonium chloride; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.5h;

4,4'-bicyclohexanone; In tetrahydrofuran; at 0 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃; for 2h;
DOI:10.1021/acs.orglett.0c00124

Reference yield:

: 189387-84-6
trans-[1,1'-bi(cyclohexane)]-4,4'-dicarbaldehyde

: 1-(3-butenyloxy)-2,3-difluoro-4-(trans-4-(trans-4-vinylcyclohexyl)cyclohexyl)methoxybenzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / -10 °C

1.2: 1 h / 5 - 10 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 2 h / -10 - 20 °C

3.1: pyridine; dmap / dichloromethane / 20 °C / Cooling with ice

4.1: potassium phosphate / N,N-dimethyl-formamide / 6 h / 100 - 130 °C

With pyridine; dmap; sodium tetrahydroborate; potassium phosphate; potassium tert-butylate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;