ethyl 3-(1-(4-carbamoyl-2-methylphenyl)-5-(4-(2-cyclopropyl-1H-imidazol-1-yl)phenyl)-1H-pyrrol-2-yl)propanoate

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Chemical Name:ethyl 3-(1-(4-carbamoyl-2-methylphenyl)-5-(4-(2-cyclopropyl-1H-imidazol-1-yl)phenyl)-1H-pyrrol-2-yl)propanoate
CAS No.:1208318-52-8
Molecular Formula:C₂₉H₃₀N₄O₃
Molecular Weight:482.582
Hs Code.:

Synonyms:ethyl 3-(1-(4-carbamoyl-2-methylphenyl)-5-(4-(2-cyclopropyl-1H-imidazol-1-yl)phenyl)-1H-pyrrol-2-yl)propanoate

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Chemical Property of ethyl 3-(1-(4-carbamoyl-2-methylphenyl)-5-(4-(2-cyclopropyl-1H-imidazol-1-yl)phenyl)-1H-pyrrol-2-yl)propanoate

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Technology Process of ethyl 3-(1-(4-carbamoyl-2-methylphenyl)-5-(4-(2-cyclopropyl-1H-imidazol-1-yl)phenyl)-1H-pyrrol-2-yl)propanoate

There total 6 articles about ethyl 3-(1-(4-carbamoyl-2-methylphenyl)-5-(4-(2-cyclopropyl-1H-imidazol-1-yl)phenyl)-1H-pyrrol-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1208318-09-5
ethyl 3-(5-(4-bromophenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoate

: 89532-38-7
2-cyclopropyl-1H-imidazole

: 1208318-52-8
ethyl 3-(1-(4-carbamoyl-2-methylphenyl)-5-(4-(2-cyclopropyl-1H-imidazol-1-yl)phenyl)-1H-pyrrol-2-yl)propanoate

Guidance literature:: With copper(I) oxide; 8-quinolinol; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 128 ℃; for 6h; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.bmcl.2011.07.103

Reference yield:

: 109152-85-4
2-Cyclopropyl-4,5-dihydro-1H-imidazol

: 1208318-52-8
ethyl 3-(1-(4-carbamoyl-2-methylphenyl)-5-(4-(2-cyclopropyl-1H-imidazol-1-yl)phenyl)-1H-pyrrol-2-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium permanganate; silica gel / acetonitrile / 20 °C

2: copper(I) oxide; 8-quinolinol; potassium carbonate / 1-methyl-pyrrolidin-2-one / 6 h / 128 °C / Inert atmosphere; Microwave irradiation

With copper(I) oxide; potassium permanganate; 8-quinolinol; silica gel; potassium carbonate; In 1-methyl-pyrrolidin-2-one; acetonitrile;
DOI:10.1016/j.bmcl.2011.07.103

Reference yield:

: 98-01-1
furfural

: 1208318-52-8
ethyl 3-(1-(4-carbamoyl-2-methylphenyl)-5-(4-(2-cyclopropyl-1H-imidazol-1-yl)phenyl)-1H-pyrrol-2-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; sodium methylate / 20 °C

2: hydrogen bromide / water; ethanol / 8 h / Reflux

3: toluene-4-sulfonic acid / ethanol / Reflux

4: potassium carbonate; 8-quinolinol; copper(I) oxide / 1-methyl-pyrrolidin-2-one / 6 h / 128 °C / Inert atmosphere; Microwave irradiation

With copper(I) oxide; methanol; 8-quinolinol; hydrogen bromide; sodium methylate; potassium carbonate; toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; ethanol; water;