2-Cyclopropyl-1H-imidazole

Base Information

• Chemical Name: 2-Cyclopropyl-1H-imidazole
• CAS No.: 89532-38-7
• Molecular Formula: C6H8N2
• Molecular Weight: 108.143
• Hs Code.: 2933290090
• Mol file: 89532-38-7.mol

Synonyms:2-Cyclopropylimidazol; 2-Cyclopropylimidazole; 1H-Imidazole,2-cyclopropyl

Chemical Property of 2-Cyclopropyl-1H-imidazole

Chemical Property:

• Melting Point: 138-139℃
• Boiling Point: 324.155 °C at 760 mmHg
• PKA: 14.39±0.10(Predicted)
• Flash Point: 181.933 °C
• PSA: 28.68000
• Density: 1.215 g/cm³
• LogP: 1.28710
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Cyclopropyl-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Cyclopropyl-1H-imidazole

There total 5 articles about 2-Cyclopropyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

Glyoxal (131543-46-9,107-22-2) + Cyclopropanecarboxaldehyde (1489-69-6) → 2-cyclopropyl-1H-imidazole (89532-38-7)

Guidance literature:

With ammonium hydroxide; In methanol; at 0 - 20 ℃;

Reference yield:

2-Cyclopropyl-4,5-dihydro-1H-imidazol (109152-85-4) → 2-cyclopropyl-1H-imidazole (89532-38-7)

Guidance literature:

With potassium permanganate; silica gel; In acetonitrile; at 20 ℃;

DOI:10.1016/j.bmcl.2011.07.103

Reference yield:

cyclopropropanecarbonitrile (5500-21-0) + 2,2-dimethoxyethylamine (22483-09-6) → 2-cyclopropyl-1H-imidazole (89532-38-7)

Guidance literature:

cyclopropropanecarbonitrile; 2,2-dimethoxyethylamine; With copper(l) chloride; at 85 ℃; for 14.5h; Cooling with ice; Inert atmosphere;

With thioacetamide; In methanol; at 45 ℃; for 1h; Inert atmosphere; Cooling with ice;

upstream raw materials:

cyclopropropanecarbonitrile

2,2-dimethoxyethylamine

Glyoxal

Cyclopropanecarboxaldehyde

Downstream raw materials:

3-cyclopropyl-1-iodo-8-[2-(4-trifluoromethyl-phenyl)-ethyl]-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine

3-cyclopropyl-1-iodo-8-[2-(4-trifluoromethyl-phenyl)-ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester

ethyl 3-(1-(4-carbamoyl-2-methylphenyl)-5-(4-(2-cyclopropyl-1H-imidazol-1-yl)phenyl)-1H-pyrrol-2-yl)propanoate

1H-Imidazole, 2-cyclopropyl-1-[[1-(3,4-dichlorophenyl)-1H-imidazol-4-yl]methyl]-

Refernces

• 1、 -. "HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS AND COMBINATIONS THEREOF". Page/Page column 130. . Retrieved 2015/07/07.
• 2、 -. "HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS". Page/Page column 115. . Retrieved 2014/01/18.