ethyl 2-oxo-6-(5-oxo-2,5-dihydrofuran-2-yl)cyclohexanecarboxylate

Base Information

• Chemical Name: ethyl 2-oxo-6-(5-oxo-2,5-dihydrofuran-2-yl)cyclohexanecarboxylate
• CAS No.: 1258209-15-2
• Molecular Formula: C₁₃H₁₆O₅
• Molecular Weight: 252.267
• Mol file: 1258209-15-2.mol

Synonyms:ethyl 2-oxo-6-(5-oxo-2,5-dihydrofuran-2-yl)cyclohexanecarboxylate

Chemical Property of ethyl 2-oxo-6-(5-oxo-2,5-dihydrofuran-2-yl)cyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-oxo-6-(5-oxo-2,5-dihydrofuran-2-yl)cyclohexanecarboxylate

There total 1 articles about ethyl 2-oxo-6-(5-oxo-2,5-dihydrofuran-2-yl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(furan-2-yloxy)-trimethylsilane (61550-02-5) + ethyl 6-oxocyclohex-1-enecarboxylate (57205-09-1) → ethyl 2-oxo-6-(5-oxo-2,5-dihydrofuran-2-yl)cyclohexanecarboxylate (1258209-15-2)

Guidance literature:

(furan-2-yloxy)-trimethylsilane; ethyl 6-oxocyclohex-1-enecarboxylate; With copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at -78 ℃; Inert atmosphere;

With ammonium chloride; In dichloromethane; water; at -78 - 20 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201000504

Reference yield: 66.0%

ethyl 2-oxo-6-(5-oxo-2,5-dihydrofuran-2-yl)cyclohexanecarboxylate (1258209-15-2) + diethyl chlorophosphate (814-49-3) → ethyl 2-(diethoxyphosphoryloxy)-6-(5-oxo-2,5-dihydrofuran-2-yl)cyclohex-1-enecarboxylate

Guidance literature:

ethyl 2-oxo-6-(5-oxo-2,5-dihydrofuran-2-yl)cyclohexanecarboxylate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

diethyl chlorophosphate; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/ejoc.201000504

Reference yield: 50.0%

ethyl 2-oxo-6-(5-oxo-2,5-dihydrofuran-2-yl)cyclohexanecarboxylate (1258209-15-2) + methyl iodide (74-88-4) → (1S,6S)-ethyl 1-methyl-2-oxo-6-((R)-5-oxo-2,5-dihydrofuran-2-yl)cyclohexanecarboxylate (1425314-23-3)

Guidance literature:

ethyl 2-oxo-6-(5-oxo-2,5-dihydrofuran-2-yl)cyclohexanecarboxylate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 0 - 25 ℃; Inert atmosphere;

DOI:10.1021/jo3020648

upstream raw materials:

(furan-2-yloxy)-trimethylsilane

ethyl 6-oxocyclohex-1-enecarboxylate

Downstream raw materials:

(R)-5-((S)-3-oxocyclohexyl)dihydrofuran-2(3H)-one

(S)-ethyl 2-((diphenoxyphosphoryl)oxy)-6-((R)-5-oxo-2,5-dihydrofuran-2-yl)cyclohex-1-enecarboxylate

(S)-2-(ethoxycarbonyl)-3-((R)-5-oxo-2,5-dihydrofuran-2-yl)cyclohex-1-en-1-yl 4-nitrobenzoate

(1S,6S)-ethyl 1-methyl-2-oxo-6-((R)-5-oxo-2,5-dihydrofuran-2-yl)cyclohexanecarboxylate