57205-09-1Relevant articles and documents
Synthetic efforts toward the bicyclo[3.2.1]octane fragment of rhodojaponin III
Webster, Caroline G.,Park, Hyeri,Ennis, Amanda F.,Hong, Jiyong
, (2021/04/22)
Rhodojaponin III is a grayanane-type diterpenoid natural product with a novel chemical scaffold. It shows potent antinociceptive activity and may represent a new class of natural non-opioid analgesics with a novel mode of action. We explored the Au(I)-cat
Preparation and double Michael addition reactions of a synthetic equivalent of the Nazarov reagent
Amat, Mercedes,Arioli, Federica,Perez, Maria,Molins, Elies,Bosch, Joan
, p. 2470 - 2473 (2013/07/04)
A synthetic equivalent of the Nazarov reagent, the silyl derivative 2, able to undergo base-catalyzed double Michael addition reactions with α,β-unsaturated carbonyl compounds has been developed. The new reagent satisfactorily reacts with unsaturated indo
Novel oxygenations with IBX
Duschek, Alexander,Kirsch, Stefan F.
scheme or table, p. 10713 - 10717 (2010/04/05)
Universal remedy: The α-hydroxylation of β-keto esters and a range of other suitably substituted carbonyl compounds can be effected in the presence of IBX (2-iodoxybenzoic acid). This novel reactivity underscores the importance of IBX as a universally applicable oxidizing agent.
PRODRUG CONSTRUCTS OF PYRIMIDINONE COMPOUNDS AS CALCILYTICS
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Page/Page column 33; 34, (2010/11/08)
Various calcilytic compounds and prodrugs of calcilytic compounds are disclosed. Calcilytic compounds are compounds capable of inhibiting calcium receptor activity. Methods for preparing these compounds, oral bioavailability of these compounds, pharmaceut
α-EWG-substituted enones: Suitable substrates for ring-closing metathesis
Toueg, Julie,Prunet, Jo?lle
, p. 2807 - 2811 (2008/02/11)
The A-ring of hexacyclinic acid has been synthesised, using a ring-closing metathesis involving an α-EWG-substituted enone as the key step. We have then explored the scope of this reaction, which gives access to various 5- and 6-membered rings. Georg Thieme Verlag Stuttgart.
Odorless diphenyl diselenide and disulfide: Syntheses and applications
Patra, Pranab K.,Shanmugasundaram, Kandasamy,Matoba, Manabu,Nishide, Kiyoharu,Kajimoto, Tetsuya,Node, Manabu
, p. 447 - 457 (2007/10/03)
Bis[4-(trimethylsilyl)phenyl]diselenide (3) and bis[4-(trimethylsilyl) phenyl]disulfide (31) are found to be odorless equivalents of the commonly used diphenyl diselenide and diphenyl disulfide, respectively. The diselenide 3 is shown to be useful in the preparation of odorless selenium(II) chloride 26 and selenium(IV) trichloride 28 that follow similar reactivity patterns to their phenyl derivatives and can be stored refrigerated under dry conditions. The corresponding selenium(II) bromide had to be prepared fresh from 3 before use. It is also shown that the trimethylsilyl group in the sulfide products can be protodesilylated quantitatively using TFA. Georg Thieme Verlag Stuttgart.
Synthesis of fused bicyclic rings by tandem radical ring expansion/cyclization: Evaluating competing intramolecular reactions
Wang, Cunxiao,Gu, Xin,Yu, Marvin S.,Curran, Dennis P.
, p. 8355 - 8370 (2007/10/03)
One- and three-carbon 'Dowd-Beckwith' ring expansions of cyclopentanones and cyclohexanones are generally successful, but tandem expansion/cyclization reactions can be compromised by competing processes. An evaluation of the competition between ring expansion, 1,5-hydrogen transfer, and 6-exo cyclization provides information on how to design successful tandem expansion cyclization sequences.
A Useful Oxidation Procedure for the Preparation of 3-Alkanoyltetronic Acids
Mittra, Asmita,Yamashita, Masayuki,Kawasaki, Ikuo,Murai, Hiromichi,Yoshioka, Tomomichi,Ohta, Shunsaku
, p. 909 - 910 (2007/10/03)
An easy and convenient synthesis of 3-alkanoyl-5-hydroxymethyltetronic acids, the salts of which have inhibitory activity against HIV-1 protease, is described and a new direct route to 1,3-dicarbonylester from cyclic β-ketoester is developed.
Enantioselective conjugate additions of silylketene acetals to 2-carboxycyclopentenones promoted by chiral Ti complexes
Bernardi, Anna,Karamfilova, Katia,Sanguinetti, Silvia,Scolastico, Carlo
, p. 13009 - 13026 (2007/10/03)
The conjugate addition of silylketeneacetals to 2-carbalkoxycyclopentenones 1 promoted by TADDOL · TiCl2 complexes was studied. The reactions are highly syn selective. The enantioselectivity depends on the size of the substrate ester group, wit
Nonclassical 5-substituted tetrahydroquinazolines as potential inhibitors of thymidylate synthase
Gangjee, Aleem,Vasudevan, Anil,Kisliuk, Roy L.
, p. 1669 - 1676 (2007/10/03)
Classical inhibitors of thymidylate synthase such as N10-propargyl- 5,8-dideazafolic acid (1), N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6- ylmethyl)-N-methylamino]-2-thenoyl)-L-glutamic acid (ZD1694, 2) and N-[2- amino-4-oxo-3,4-dihydro(py