Technology Process of (42S,45S)-16,26-bis(benzyloxy)-4(2,5)-piperazina-1,2(1,3)-dibenzenacyclopentaphane-43,46-dione
There total 15 articles about (42S,45S)-16,26-bis(benzyloxy)-4(2,5)-piperazina-1,2(1,3)-dibenzenacyclopentaphane-43,46-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate; bis(pinacol)diborane;
In
dimethyl sulfoxide;
at 90 ℃;
for 19h;
Reagent/catalyst;
Solvent;
Catalytic behavior;
Inert atmosphere;
DOI:10.1021/acs.orglett.8b00894
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: ammonium hydroxide; iodine / ethanol / 3 h / 0 °C
2.1: thionyl chloride / 16 h / Reflux
3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 16 h / Inert atmosphere
4.1: formic acid / 2 h
4.2: 3 h / Reflux
5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere
6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate; bis(pinacol)diborane / dimethyl sulfoxide / 16 h / 90 °C / Inert atmosphere
With
ammonium hydroxide; formic acid; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; iodine; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; bis(pinacol)diborane;
In
ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
6.1: Miyaura-Suzuki reaction;
DOI:10.1021/ol300831t
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetone / 0.25 h / 20 °C
1.2: 2 h / 60 °C
2.1: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
3.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
4.1: formic acid / 20 °C
5.1: iso-butanol; toluene / 14 h / 105 °C
6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate; bis(pinacol)diborane / dimethyl sulfoxide / 19 h / 90 °C / Inert atmosphere
With
formic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; bis(pinacol)diborane; lithium hydroxide;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene; iso-butanol;
DOI:10.1021/acs.orglett.8b00894
