4-(4-fluoro-2-methoxyphenyl)-N-{3-[(methylsulfanyl)methyl]phenyl}-1,3,5-triazin-2-amine

Base Information

Chemical Name:4-(4-fluoro-2-methoxyphenyl)-N-{3-[(methylsulfanyl)methyl]phenyl}-1,3,5-triazin-2-amine
CAS No.:1415249-81-8
Molecular Formula:C₁₈H₁₇FN₄OS
Molecular Weight:356.424
Hs Code.:

Synonyms:4-(4-fluoro-2-methoxyphenyl)-N-{3-[(methylsulfanyl)methyl]phenyl}-1,3,5-triazin-2-amine

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Chemical Property of 4-(4-fluoro-2-methoxyphenyl)-N-{3-[(methylsulfanyl)methyl]phenyl}-1,3,5-triazin-2-amine

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Technology Process of 4-(4-fluoro-2-methoxyphenyl)-N-{3-[(methylsulfanyl)methyl]phenyl}-1,3,5-triazin-2-amine

There total 5 articles about 4-(4-fluoro-2-methoxyphenyl)-N-{3-[(methylsulfanyl)methyl]phenyl}-1,3,5-triazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1415249-80-7
4-chloro-N-{3-[(methylsulfanyl)methyl]phenyl}-1,3,5-triazin-2-amine

: 179899-07-1
4-fluoro-2-methoxyphenylboronic acid

: 1415249-81-8
4-(4-fluoro-2-methoxyphenyl)-N-{3-[(methylsulfanyl)methyl]phenyl}-1,3,5-triazin-2-amine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 100 ℃; for 1.5h; Sealed tube; Inert atmosphere;
DOI:10.1055/s-0037-1610316

Reference yield:

: 619-23-8
3-Nitrobenzyl chloride

: 1415249-81-8
4-(4-fluoro-2-methoxyphenyl)-N-{3-[(methylsulfanyl)methyl]phenyl}-1,3,5-triazin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 3 h / -15 - 20 °C

2: iron; hydrogenchloride / ethanol; water / 3 h / Reflux

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol; tetrahydrofuran / 0.5 h / 0 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 1.5 h / 100 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; isopropyl alcohol; 4: |Suzuki Coupling;
DOI:10.1055/s-0037-1610316

Reference yield:

: 51392-54-2
1-[(methylsulfanyl)methyl]-3-nitrobenzene

: 1415249-81-8
4-(4-fluoro-2-methoxyphenyl)-N-{3-[(methylsulfanyl)methyl]phenyl}-1,3,5-triazin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: iron; hydrogenchloride / ethanol; water / 3 h / Reflux

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol; tetrahydrofuran / 0.5 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 1.5 h / 100 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; isopropyl alcohol; 3: |Suzuki Coupling;
DOI:10.1055/s-0037-1610316