tert-butyl 2-[(diphenoxyphosphoryl)oxy]-6-ethyl-3-phenyl-1H-thieno[2,3-b][1,4]thiazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 2-[(diphenoxyphosphoryl)oxy]-6-ethyl-3-phenyl-1H-thieno[2,3-b][1,4]thiazine-1-carboxylate
CAS No.:336626-83-6
Molecular Formula:C₃₁H₃₀NO₆PS₂
Molecular Weight:607.688
Hs Code.:

Synonyms:tert-butyl 2-[(diphenoxyphosphoryl)oxy]-6-ethyl-3-phenyl-1H-thieno[2,3-b][1,4]thiazine-1-carboxylate

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Chemical Property of tert-butyl 2-[(diphenoxyphosphoryl)oxy]-6-ethyl-3-phenyl-1H-thieno[2,3-b][1,4]thiazine-1-carboxylate

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Technology Process of tert-butyl 2-[(diphenoxyphosphoryl)oxy]-6-ethyl-3-phenyl-1H-thieno[2,3-b][1,4]thiazine-1-carboxylate

There total 6 articles about tert-butyl 2-[(diphenoxyphosphoryl)oxy]-6-ethyl-3-phenyl-1H-thieno[2,3-b][1,4]thiazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 336626-81-4
tert-butyl 6-ethyl-2-oxo-3-phenyl-2,3-dihydro-1H-thieno[2,3-b][1,4]thiazine-1-carboxylate

: 336626-83-6
tert-butyl 2-[(diphenoxyphosphoryl)oxy]-6-ethyl-3-phenyl-1H-thieno[2,3-b][1,4]thiazine-1-carboxylate

Guidance literature:: tert-butyl 6-ethyl-2-oxo-3-phenyl-2,3-dihydro-1H-thieno[2,3-b][1,4]thiazine-1-carboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

chlorophosphoric acid diphenyl ester; In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.3987/COM-00-9072

Reference yield:

: 4870-65-9,31302-84-8
2-bromophenylacetic acid

: 336626-83-6
tert-butyl 2-[(diphenoxyphosphoryl)oxy]-6-ethyl-3-phenyl-1H-thieno[2,3-b][1,4]thiazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Na₂S*9H₂O / ethanol / 1 h

1.2: 79 percent / ethanol / 14 h

2.1: 32 percent / iron powder / acetic acid / 0.5 h / 110 °C

3.1: 32 percent / triethylsilane / trifluoroacetic acid / 14 h

4.1: 28 percent / triethylamine; dimethylaminopyridine / 1,2-dichloro-ethane / 3 h / 20 °C

5.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

5.2: 17 percent / tetrahydrofuran / 0.5 h / -78 °C

With triethylsilane; dmap; sodium sulfide; n-butyllithium; iron; triethylamine; diisopropylamine; In tetrahydrofuran; ethanol; hexane; acetic acid; 1,2-dichloro-ethane; trifluoroacetic acid;
DOI:10.3987/COM-00-9072

Reference yield:

: 42456-75-7
5-acetyl-2-chloro-3-nitrothiophene

: 336626-83-6
tert-butyl 2-[(diphenoxyphosphoryl)oxy]-6-ethyl-3-phenyl-1H-thieno[2,3-b][1,4]thiazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Na₂S*9H₂O / ethanol / 1 h

1.2: 79 percent / ethanol / 14 h

2.1: 32 percent / iron powder / acetic acid / 0.5 h / 110 °C

3.1: 32 percent / triethylsilane / trifluoroacetic acid / 14 h

4.1: 28 percent / triethylamine; dimethylaminopyridine / 1,2-dichloro-ethane / 3 h / 20 °C

5.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

5.2: 17 percent / tetrahydrofuran / 0.5 h / -78 °C

With triethylsilane; dmap; sodium sulfide; n-butyllithium; iron; triethylamine; diisopropylamine; In tetrahydrofuran; ethanol; hexane; acetic acid; 1,2-dichloro-ethane; trifluoroacetic acid;
DOI:10.3987/COM-00-9072