[(2S,4R)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-yl]-oxo-acetic acid methyl ester

Base Information

Chemical Name:[(2S,4R)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-yl]-oxo-acetic acid methyl ester
CAS No.:727709-17-3
Molecular Formula:C₂₆H₄₀N₂O₇Si
Molecular Weight:520.698
Hs Code.:

Synonyms:[(2S,4R)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-yl]-oxo-acetic acid methyl ester

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Chemical Property of [(2S,4R)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-yl]-oxo-acetic acid methyl ester

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Technology Process of [(2S,4R)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-yl]-oxo-acetic acid methyl ester

There total 6 articles about [(2S,4R)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-yl]-oxo-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 67-56-1
methanol

: ((S)-1-{(2S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-[2-cyano-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid benzyl ester

: 727709-17-3
[(2S,4R)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-yl]-oxo-acetic acid methyl ester

Guidance literature:: With ozone; In dichloromethane;
DOI:10.1055/s-2004-822906

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 727709-17-3
[(2S,4R)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-yl]-oxo-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / HOBt; EDCI; N-methylmorpholine / CH₂Cl₂

2: 96 percent / DBU / acetonitrile

3: 94 percent / NaOH / methanol

4: 87 percent / DMAP; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CH₂Cl₂

5: 66 percent / O₃ / CH₂Cl₂

With 4-methyl-morpholine; dmap; sodium hydroxide; benzotriazol-1-ol; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; acetonitrile;
DOI:10.1055/s-2004-822906

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 727709-17-3
[(2S,4R)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-yl]-oxo-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / HOBt; EDCI; N-methylmorpholine / CH₂Cl₂

2: 96 percent / DBU / acetonitrile

3: 94 percent / NaOH / methanol

4: 87 percent / DMAP; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CH₂Cl₂

5: 66 percent / O₃ / CH₂Cl₂

With 4-methyl-morpholine; dmap; sodium hydroxide; benzotriazol-1-ol; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; acetonitrile;
DOI:10.1055/s-2004-822906