3-chloro-N-[[1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropyl]methyl]pyridine-2-carboxamide

Base Information

Chemical Name:3-chloro-N-[[1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropyl]methyl]pyridine-2-carboxamide
CAS No.:1433966-01-8
Molecular Formula:C₁₇H₁₃ClF₄N₂O
Molecular Weight:372.75
Hs Code.:

Synonyms:3-chloro-N-[[1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropyl]methyl]pyridine-2-carboxamide

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Chemical Property of 3-chloro-N-[[1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropyl]methyl]pyridine-2-carboxamide

Chemical Property:

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Technology Process of 3-chloro-N-[[1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropyl]methyl]pyridine-2-carboxamide

There total 3 articles about 3-chloro-N-[[1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropyl]methyl]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57266-69-0
3-chloropyridine-2-carboxylic acid

: 1433966-82-5
[1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropyl]methanamine

: 1433966-01-8
3-chloro-N-[[1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropyl]methyl]pyridine-2-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 1314700-27-0
1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropanecarbonitrile

: 1433966-01-8
3-chloro-N-[[1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropyl]methyl]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 10 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; dichloromethane;

Reference yield:

: 239087-11-7
[2-fluoro-4-(trifluoromethyl)phenyl]acetonitrile

: 1433966-01-8
3-chloro-N-[[1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropyl]methyl]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 2.5 h / 0 - 50 °C

2: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 10 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;