Technology Process of 2-[(1,3-dioxo-indan-2-ylidene)-hydroxy-methyl]-benzoic acid ethyl ester
There total 10 articles about 2-[(1,3-dioxo-indan-2-ylidene)-hydroxy-methyl]-benzoic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 7 steps
1: 72 percent / phosphorus pentachloride / CHCl3 / 0.25 h / Heating
2: 30 percent / aluminum chloride; ferric chloride / 0.67 h / 25 - 225 °C / 3 - 5 Torr
3: 52 percent / chromium(VI) oxide / H2O; acetic acid / 2 h / 50 - 55 °C
4: 58 percent / NBS; AIBN; bromine / CCl4 / 90 h / Heating
5: acetic acid / 4 h / Heating
6: 0.260 g / water / CH2Cl2
7: ethanol / 2 h / 25 °C
With
chromium(VI) oxide; N-Bromosuccinimide; aluminium trichloride; 2,2'-azobis(isobutyronitrile); phosphorus pentachloride; water; bromine; iron(III) chloride;
In
tetrachloromethane; ethanol; dichloromethane; chloroform; water; acetic acid;
1: Substitution / 2: Cyclization / 3: Oxidation / 4: Bromination / 5: Substitution / 6: Hydrolysis / 7: Rearrangement;
DOI:10.1021/jo990867j
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 85 percent / sodium hydroxide / ethanol; H2O / 6 h / 90 °C
2: 72 percent / phosphorus pentachloride / CHCl3 / 0.25 h / Heating
3: 30 percent / aluminum chloride; ferric chloride / 0.67 h / 25 - 225 °C / 3 - 5 Torr
4: 52 percent / chromium(VI) oxide / H2O; acetic acid / 2 h / 50 - 55 °C
5: 58 percent / NBS; AIBN; bromine / CCl4 / 90 h / Heating
6: acetic acid / 4 h / Heating
7: 0.260 g / water / CH2Cl2
8: ethanol / 2 h / 25 °C
With
chromium(VI) oxide; sodium hydroxide; N-Bromosuccinimide; aluminium trichloride; 2,2'-azobis(isobutyronitrile); phosphorus pentachloride; water; bromine; iron(III) chloride;
In
tetrachloromethane; ethanol; dichloromethane; chloroform; water; acetic acid;
1: Hydrolysis / 2: Substitution / 3: Cyclization / 4: Oxidation / 5: Bromination / 6: Substitution / 7: Hydrolysis / 8: Rearrangement;
DOI:10.1021/jo990867j
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium ethoxide / ethanol / 0.5 h
1.2: 98 percent / ethanol / 0 - 25 °C
2.1: 85 percent / sodium hydroxide / ethanol; H2O / 6 h / 90 °C
3.1: 72 percent / phosphorus pentachloride / CHCl3 / 0.25 h / Heating
4.1: 30 percent / aluminum chloride; ferric chloride / 0.67 h / 25 - 225 °C / 3 - 5 Torr
5.1: 52 percent / chromium(VI) oxide / H2O; acetic acid / 2 h / 50 - 55 °C
6.1: 58 percent / NBS; AIBN; bromine / CCl4 / 90 h / Heating
7.1: acetic acid / 4 h / Heating
8.1: 0.260 g / water / CH2Cl2
9.1: ethanol / 2 h / 25 °C
With
chromium(VI) oxide; sodium hydroxide; N-Bromosuccinimide; aluminium trichloride; 2,2'-azobis(isobutyronitrile); phosphorus pentachloride; water; bromine; sodium ethanolate; iron(III) chloride;
In
tetrachloromethane; ethanol; dichloromethane; chloroform; water; acetic acid;
1.1: Metallation / 1.2: Alkylation / 2.1: Hydrolysis / 3.1: Substitution / 4.1: Cyclization / 5.1: Oxidation / 6.1: Bromination / 7.1: Substitution / 8.1: Hydrolysis / 9.1: Rearrangement;
DOI:10.1021/jo990867j
