4372-32-1Relevant academic research and scientific papers
Mixed-ligand manganese(II)-phenolate complexes: Study of DNA cleavage, cytotoxic activity, and induction of apoptosis
Gao, En-Jun,Zhang, Ying,Lin, Lin,Wang, Ren-Shu,Dai, Lei,Liang, Qi,Zhu, Ming-Chang,Wang, Mei-Lin,Liu, Lei,He, Wen-Xuan,Zhang, Yan-Jin
, p. 3992 - 4005 (2011)
Two manganese complexes, [Mn(L1)2(dibe) 2](L1) (1) and [Mn(L2)2(dibe) 2] (2) (where L1= 2,2'- bipyridine (bipy), L 2=1,10-phenanthroline (phen)), were synthesized by using a carboxylic acid ligand (dibe= 2,2-dibenzylmalonate acid). The two complexes were characterized using IR, elemental analysis, and X-ray crystallography. Fluorescence analysis indicates that the two complexes can bind to HeLa cell DNA (HC-DNA), and gel electrophoresis assay demonstrates the ability of the complexes to cleave the HC-DNA. The two complexes exhibit cytotoxic specificity and significant cancer cell inhibitory rate. Furthermore, apoptotic tests demonstrate that these two complexes have apoptotic effects on HeLa cells. 2011 Taylor & Francis.
Syntheses, Structures and Optoelectronic Properties of Spiroconjugated Cyclic Ketones
Wilbuer, Jennifer,Schnakenburg, Gregor,Esser, Birgit
, p. 2404 - 2412 (2016/06/01)
Synthetic investigations towards spiroconjugated ketones and derivatives thereof are presented. These studies led to the development of a short procedure for the synthesis of spiroconjugated tetraketone 1 in two steps with 10 % overall yield and the first-time synthesis of spirocyclic trindone 2. The optoelectronic properties of these compounds based on spectroscopic and electrochemical measurements in combination with DFT calculations as well as their molecular structures in the solid state are presented and discussed.
Some unusual reactions of Meldrum's acid. Synthesis of cinnamic acids, coumarins and 2-benzyl-1-indanone
Mahulikar,Mane
, p. 12 - 14 (2007/10/03)
The use of Meldrum's acid (1) in the synthesis of the substituted cinnamic acid 3 and malonic acid 4, the coumarins 8 and 9, and of 2-benzyl-1-indanone (13), is reported. The structure of benzylidene benzalmalonate is corrected to 14.
Synthesis of a novel spiro bisphosphinite ligand and its application in Rh-catalyzed asymmetric hydrogenation
Guo, Zhenqiu,Guan, Xiaoyu,Chen, Zhiyong
, p. 468 - 473 (2007/10/03)
A novel, chiral bisphosphinite ligand (R)-SpiroBIP has been synthesized. The rhodium complex of the ligand was found to be highly enantioselective in the asymmetric hydrogenation of α-dehydroamino acid derivatives.
Microwave assisted hydrolysis of Meldrum's acid derivatives and decarboxylation of derived malonic acids
Helavi,Solabannavar,Desai,Mane
, p. 174 - 175 (2007/10/03)
Microwave induced hydrolysis of alkyl Medrum's acids and decarboxylation of derived malonic acids using poly-4-vinylpyridine as a catalyst gives high yields of carboxylic acids in a short time.
Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol
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Page column 6-7, (2010/02/05)
A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C15H30N2O4 and is prepared by reacting a first quantity of 2-amino-2-methyl-1-propanol with a second quantity of a di-substituted malonyl dichloride (i.e., diethylmalonyl dichloride), preferably in ethyl acetate as solvent. A tetraamido macrocycle is prepared from the diamidodiol in two steps by oxidizing the diamidodiol to form a diacid followed by coupling using a known procedure of the diacid with an aryl diamine (e.g., 1,2-diaminobenzene) to yield the tetraamido macrocycle.
Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol
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, (2008/06/13)
A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C15H30N2O4and is prepared by reacting a first quantity of 2-amino-2-methyl-1-pr
Synthesis, structure, and nucleophile-induced rearrangements of spiroketones
Maslak, Przemyslaw,Varadarajan, Sridhar,Burkey, Jeffrey D.
, p. 8201 - 8209 (2007/10/03)
Three tetraketones based on the 2,2'-spirobiindan-1,1',3,3'-tetraone skeleton were prepared and investigated. All three compounds show spiroconjugation between their perpendicular π-networks. The interaction results in lowering of the energy of the LUMO of the systems by ca. 0.2-0.3 eV as compared to non-spiroconjugated models. The spiroketones are susceptible to nucleophile-induced retro-Claisen condensations that lead to molecular rearrangements destroying spiro connectivity.
Role of Substituents in Copper(II) Extraction with N,N'-Bis(8-quinolyl)malonamides
Hirose, Takuji,Hiratani, Kazuhisa,Kasuga, Kazuyuki,Saito, Kiyoshi,Koike, Tohru,et al.
, p. 2679 - 2684 (2007/10/02)
It has been found that substituents on N,N'-bis (8-quinolyl)malonamide play an important role in copper(II) extraction: among the substituents studied, benzyl groups dramatically increased extractability of the malonamide complex.The role of substituents is discussed on the basis of the results of titration and 1H NMR measurements of copper(II) or nickel(II) complexes as well as copper(II)-extraction experiments.Intramolecular interactions between ? electrons of the benzyl group and the metal centre of the complex are proposed to occur.
