Technology Process of (1R,2R,3R,4S,6R)-3-O-acetyl-1,2-di-O-benzyl-6-benzyloxymethyl-4-iodocyclohexane-1,2,3-triol
There total 7 articles about (1R,2R,3R,4S,6R)-3-O-acetyl-1,2-di-O-benzyl-6-benzyloxymethyl-4-iodocyclohexane-1,2,3-triol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap;
In
pyridine; dichloromethane;
for 24h;
Ambient temperature;
DOI:10.1039/P19940002017
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) THF, 0 deg C, 1 h, 2.) 60 deg C, 12 h
2: 90 percent / aq. TFA / CH2Cl2 / 24 h / Ambient temperature
3: 93 percent / Et3N, thionyl chloride / CH2Cl2 / 0.08 h / 0 °C
4: 89 percent / aq. RuCl3, NaIO4 / CCl4; acetonitrile / 1 h / 0 °C
5: 1.) Bu4NI, 2.) conc. H2SO4 / 1.) THF, reflux, 6 h, 2.) H2O, 60 deg C, 30 min
6: 95 percent / DMAP / pyridine; CH2Cl2 / 24 h / Ambient temperature
With
dmap; ruthenium trichloride; sodium periodate; thionyl chloride; sulfuric acid; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; trifluoroacetic acid;
In
pyridine; tetrachloromethane; dichloromethane; acetonitrile;
DOI:10.1039/P19940002017
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) THF, 0 deg C, 1 h, 2.) 60 deg C, 12 h
2: 90 percent / aq. TFA / CH2Cl2 / 24 h / Ambient temperature
3: 93 percent / Et3N, thionyl chloride / CH2Cl2 / 0.08 h / 0 °C
4: 89 percent / aq. RuCl3, NaIO4 / CCl4; acetonitrile / 1 h / 0 °C
5: 1.) Bu4NI, 2.) conc. H2SO4 / 1.) THF, reflux, 6 h, 2.) H2O, 60 deg C, 30 min
6: 95 percent / DMAP / pyridine; CH2Cl2 / 24 h / Ambient temperature
With
dmap; ruthenium trichloride; sodium periodate; thionyl chloride; sulfuric acid; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; trifluoroacetic acid;
In
pyridine; tetrachloromethane; dichloromethane; acetonitrile;
DOI:10.1039/P19940002017
