(E)-2-ethyl-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-3H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:(E)-2-ethyl-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-3H-imidazo[4,5-b]pyridine
CAS No.:1197879-16-5
Molecular Formula:C₂₇H₃₇N₅
Molecular Weight:431.624
Hs Code.:

Synonyms:(E)-2-ethyl-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-3H-imidazo[4,5-b]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-ethyl-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-3H-imidazo[4,5-b]pyridine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (E)-2-ethyl-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-3H-imidazo[4,5-b]pyridine

There total 7 articles about (E)-2-ethyl-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 4318-42-7
1-(1-methylethyl)piperazine

: 1197880-08-2
(E)-3-(4-((2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)prop-2-en-1-ol

: 1197879-16-5
(E)-2-ethyl-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; (cyanomethyl)trimethyl-phosphonium iodide; at 120 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2017.06.050

Reference yield:

: 7144-20-9
2-Amino-4,6-dimethylnicotinamide

: 1197879-16-5
(E)-2-ethyl-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / methanol / 0.5 h / 20 °C / Inert atmosphere

1.2: 16 h / -5 - 20 °C / Inert atmosphere

2.1: propionic acid; magnesium chloride / 16 h / Inert atmosphere; Heating

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

4.1: dicyclohexylmethylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 0.08 h / 130 °C / Inert atmosphere; Microwave irradiation

5.1: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -78 °C / Inert atmosphere

6.1: (cyanomethyl)trimethyl-phosphonium iodide; N-ethyl-N,N-diisopropylamine / 2 h / 120 °C / Inert atmosphere

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; dicyclohexylmethylamine; sodium hydride; diisobutylaluminium hydride; propionic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide; magnesium chloride; (cyanomethyl)trimethyl-phosphonium iodide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil; 4.1: |Heck Reaction;
DOI:10.1016/j.bmc.2017.06.050

Reference yield:

: 133240-06-9
5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine

: 1197879-16-5
(E)-2-ethyl-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: dicyclohexylmethylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 0.08 h / 130 °C / Inert atmosphere; Microwave irradiation

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -78 °C / Inert atmosphere

4.1: (cyanomethyl)trimethyl-phosphonium iodide; N-ethyl-N,N-diisopropylamine / 2 h / 120 °C / Inert atmosphere

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; dicyclohexylmethylamine; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; (cyanomethyl)trimethyl-phosphonium iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil; 2.1: |Heck Reaction;
DOI:10.1016/j.bmc.2017.06.050