(8R)-5,6,7,8-tetrahydro-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

Base Information

Chemical Name:(8R)-5,6,7,8-tetrahydro-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridine
CAS No.:1242309-26-7
Molecular Formula:C₂₃H₂₁F₃N₆O
Molecular Weight:454.455
Hs Code.:

Synonyms:(8R)-5,6,7,8-tetrahydro-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

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Chemical Property of (8R)-5,6,7,8-tetrahydro-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

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Technology Process of (8R)-5,6,7,8-tetrahydro-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

There total 9 articles about (8R)-5,6,7,8-tetrahydro-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242313-36-5
C₂₃H₂₁F₃N₆O

: 1242309-26-7
(8R)-5,6,7,8-tetrahydro-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

: 1242309-25-6
(8S)-5,6,7,8-tetrahydro-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

Guidance literature:: With isopropylamine; In methanol; carbon dioxide; Resolution of racemate;

Reference yield:

: 1124382-72-4
8-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-ylamine

: 1242309-26-7
(8R)-5,6,7,8-tetrahydro-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

: 1242309-25-6
(8S)-5,6,7,8-tetrahydro-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.17 h / 150 °C / Microwave irradiation

2: palladium on activated charcoal; hydrogenchloride / methanol; isopropyl alcohol / 16 h / 50 °C

3: sodium nitrite; hydrogen bromide; copper(I) bromide / water

4: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

5: chiral SFC / Resolution of racemate

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen bromide; sodium hydrogencarbonate; copper(I) bromide; sodium nitrite; In 1,4-dioxane; methanol; water; isopropyl alcohol; 1: |Suzuki-Miyaura Coupling / 3: |Sandmeyer Reaction / 4: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.06.100

Reference yield:

: 13534-99-1
2-Amino-3-bromopyridine

: 1242309-26-7
(8R)-5,6,7,8-tetrahydro-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

: 1242309-25-6
(8S)-5,6,7,8-tetrahydro-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-8-[2-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1: 1,4-dioxane / 12 h / 20 °C

2: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol

3: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.17 h / 150 °C / Microwave irradiation

4: palladium on activated charcoal; hydrogenchloride / methanol; isopropyl alcohol / 16 h / 50 °C

5: sodium nitrite; hydrogen bromide; copper(I) bromide / water

6: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

7: chiral SFC / Resolution of racemate

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydroxylamine hydrochloride; hydrogen bromide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; copper(I) bromide; sodium nitrite; In 1,4-dioxane; methanol; water; isopropyl alcohol; 3: |Suzuki-Miyaura Coupling / 5: |Sandmeyer Reaction / 6: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.06.100