3-(4-chlorophenyl)-1,6-dimethylpyrimido[4,5-c]pyridazine-5,7(1H,6H)-dione

Base Information

• Chemical Name: 3-(4-chlorophenyl)-1,6-dimethylpyrimido[4,5-c]pyridazine-5,7(1H,6H)-dione
• CAS No.: 68871-18-1
• Molecular Formula: C₁₄H₁₁ClN₄O₂
• Molecular Weight: 302.72

Synonyms:3-(4-chlorophenyl)-1,6-dimethylpyrimido[4,5-c]pyridazine-5,7(1H,6H)-dione

Chemical Property of 3-(4-chlorophenyl)-1,6-dimethylpyrimido[4,5-c]pyridazine-5,7(1H,6H)-dione

Chemical Property:

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Technology Process of 3-(4-chlorophenyl)-1,6-dimethylpyrimido[4,5-c]pyridazine-5,7(1H,6H)-dione

There total 8 articles about 3-(4-chlorophenyl)-1,6-dimethylpyrimido[4,5-c]pyridazine-5,7(1H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

6-[N-[(E)-(4-chlorophenyl)methyleneamino]-N-methylamino]-3-methyl-1H-pyrimidine-2,4-dione (32502-54-8) + orthoformic acid triethyl ester (122-51-0) → 3-(4-chlorophenyl)-1,6-dimethylpyrimido[4,5-c]pyridazine-5,7(1H,6H)-dione (68871-18-1)

Guidance literature:

In N,N-dimethyl-formamide; for 10h; Heating;

DOI:10.1248/cpb.29.379

Reference yield: 22.0%

1-(4-chloro-phenyl)-2,2-dihydroxy-ethanone (4996-21-8) + 3-methyl-6-(1-methylhydrazinyl)pyrimidine-2,4(1H,3H)-dione (42747-84-2) → 3-(4-chlorophenyl)-1,6-dimethylpyrimido[4,5-c]pyridazine-5,7(1H,6H)-dione (68871-18-1)

Guidance literature:

In 1,2-dichloro-ethane; Reflux;

DOI:10.1016/j.tetlet.2010.01.007

Reference yield:

3-(4-Chloro-phenyl)-1-methyl-1H-pyrimido[4,5-c]pyridazine-5,7-dione (81976-00-3) + methyl iodide (74-88-4) → 3-(4-chlorophenyl)-1,6-dimethylpyrimido[4,5-c]pyridazine-5,7(1H,6H)-dione (68871-18-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 3h; Yield given;

DOI:10.1248/cpb.30.172

upstream raw materials:

3-(4-Chloro-phenyl)-1,6-dimethyl-4,8-dihydro-1H-pyrimido[4,5-c]pyridazine-5,7-dione

6-[N-[(E)-(4-chlorophenyl)methyleneamino]-N-methylamino]-3-methyl-1H-pyrimidine-2,4-dione

orthoformic acid triethyl ester

4-chlorobenzoylmethyl bromide

Downstream raw materials:

3-(4-Chloro-phenyl)-1,6-dimethyl-1H,8H-pyrimido[4,5-c]pyridazine-4,5,7-trione

3-(4-Chloro-phenyl)-1,6-dimethyl-4,8-dihydro-1H-pyrimido[4,5-c]pyridazine-5,7-dione

2-(4-Chloro-phenyl)-4,7-dimethyl-1a,4-dihydro-1-oxa-3,4,5,7-tetraaza-cyclopropa[d]naphthalene-6,8-dione

6-(4-Chloro-phenyl)-4-hydroxy-2-methyl-2H-pyridazin-3-one

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