trans-3-ethyl-1-(2-hydroxyethyl)-2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal

Base Information

Chemical Name:trans-3-ethyl-1-(2-hydroxyethyl)-2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal
CAS No.:132113-30-5
Molecular Formula:C₂₅H₃₀N₂O₅S
Molecular Weight:470.59
Hs Code.:

Synonyms:trans-3-ethyl-1-(2-hydroxyethyl)-2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal

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Chemical Property of trans-3-ethyl-1-(2-hydroxyethyl)-2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal

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Technology Process of trans-3-ethyl-1-(2-hydroxyethyl)-2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal

There total 6 articles about trans-3-ethyl-1-(2-hydroxyethyl)-2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 132113-33-8
3-ethyl-2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal

: 540-51-2
2-bromoethanol

: 132113-30-5
trans-3-ethyl-1-(2-hydroxyethyl)-2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal

Guidance literature:: With potassium carbonate; In ethanol; for 15h; Heating;
DOI:10.1016/S0040-4039(00)97469-0

Reference yield: 12.0%

: 132113-33-8
3-ethyl-2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal

: 540-51-2
2-bromoethanol

: 132113-30-5
trans-3-ethyl-1-(2-hydroxyethyl)-2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal

: 136061-57-9
trans-1-(2-hydroxyethyl)-2-(3-indolyl)-4-piperidone ethylene acetal

Guidance literature:: With potassium carbonate; In ethanol; for 15h; Heating;
DOI:10.1021/jo00022a015

Reference yield:

: 80360-20-9
1-(phenylsulfonyl)indole-3-carbaldehyde

: 132113-30-5
trans-3-ethyl-1-(2-hydroxyethyl)-2-<1-(phenylsulfonyl)-3-indolyl>-4-piperidone ethylene acetal

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / a.) 0 deg C, 15 min, b.) r. t., overnight, c.) 19 h, reflux

2: p-TsOH / benzene

3: 70 percent / K₂CO₃ / ethanol / 15 h / Heating

With potassium carbonate; toluene-4-sulfonic acid; In ethanol; benzene;
DOI:10.1021/jo00022a015