(2R,5R)-1-benzoyl-2-(1,1-dimethylethyl)-3-methyl-5-(3-bromopropyl)-4-imidazolidinone

Base Information

• Chemical Name: (2R,5R)-1-benzoyl-2-(1,1-dimethylethyl)-3-methyl-5-(3-bromopropyl)-4-imidazolidinone
• CAS No.: 163705-94-0
• Molecular Formula: C₁₈H₂₅BrN₂O₂
• Molecular Weight: 381.313
• Mol file: 163705-94-0.mol

Synonyms:(2R,5R)-1-benzoyl-2-(1,1-dimethylethyl)-3-methyl-5-(3-bromopropyl)-4-imidazolidinone

Chemical Property of (2R,5R)-1-benzoyl-2-(1,1-dimethylethyl)-3-methyl-5-(3-bromopropyl)-4-imidazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (2R,5R)-1-benzoyl-2-(1,1-dimethylethyl)-3-methyl-5-(3-bromopropyl)-4-imidazolidinone

There total 1 articles about (2R,5R)-1-benzoyl-2-(1,1-dimethylethyl)-3-methyl-5-(3-bromopropyl)-4-imidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(2R)-1-benzoyl-2-(1,1-dimethylethyl)-3-methyl-4-imidazolidinone (101055-57-6) + 1,3-dibromo-propane (109-64-8) → (2R,5R)-1-benzoyl-2-(1,1-dimethylethyl)-3-methyl-5-(3-bromopropyl)-4-imidazolidinone (163705-94-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; 1.) -78 deg C, 25 min, 2.) -78 deg C, 1 h; 20 deg C, overnight;

DOI:10.1021/jo00098a045

Reference yield: 31.0%

(1R,4S)-<(1,7,7-Trimethylbicyclo<2.2.1>hept-2-ylidenamino)methyl>phosphonsaeure-diethylester (104549-54-4,139563-58-9) + (2R,5R)-1-benzoyl-2-(1,1-dimethylethyl)-3-methyl-5-(3-bromopropyl)-4-imidazolidinone (163705-94-0) → diethyl <(2R,5R,1'S,4'S,1''S)-4-<1-benzoyl-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidin-5-yl>-1-<(1,7,7-trimethylbicyclo<2.2.1>hept-2-ylidene)amino>butyl>phosphonate + diethyl <(2R,5R,1'S,4'S,1''R)-4-<1-benzoyl-2-(1,1-dimethylethyl)-3-methyl-4-oxoimidazolidin-5-yl>-1-<(1,7,7-trimethylbicyclo<2.2.1>hept-2-ylidene)amino>butyl>phosphonate

Guidance literature:

With n-butyllithium; In tetrahydrofuran; 1.) -78 deg C, 25 min, 2.) -78 deg C, 1 h; 20 deg C, overnight;

DOI:10.1021/jo00098a045

upstream raw materials:

(2R)-1-benzoyl-2-(1,1-dimethylethyl)-3-methyl-4-imidazolidinone

1,3-dibromo-propane