(S)-2-((S)-(tert-butyldimethylsilyloxy)(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)methyl)-4-methoxy-4-oxobutanoic acid

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Chemical Name:(S)-2-((S)-(tert-butyldimethylsilyloxy)(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)methyl)-4-methoxy-4-oxobutanoic acid
CAS No.:1428741-21-2
Molecular Formula:C₂₅H₄₄O₇Si₂
Molecular Weight:512.791
Hs Code.:

Synonyms:(S)-2-((S)-(tert-butyldimethylsilyloxy)(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)methyl)-4-methoxy-4-oxobutanoic acid

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Chemical Property of (S)-2-((S)-(tert-butyldimethylsilyloxy)(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)methyl)-4-methoxy-4-oxobutanoic acid

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Technology Process of (S)-2-((S)-(tert-butyldimethylsilyloxy)(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)methyl)-4-methoxy-4-oxobutanoic acid

There total 4 articles about (S)-2-((S)-(tert-butyldimethylsilyloxy)(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)methyl)-4-methoxy-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1428741-17-6
(3S,4S)-methyl 4-(tert-butyldimethylsilyloxy)-4-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)butanoate

: 1428741-21-2
(S)-2-((S)-(tert-butyldimethylsilyloxy)(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)methyl)-4-methoxy-4-oxobutanoic acid

Guidance literature:: With lithium hydroxide monohydrate; dihydrogen peroxide; In tetrahydrofuran; water; at 0 - 30 ℃; for 10h; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.02.044

Reference yield:

: methyl 4-[(S)-4-isopropyl-2-oxooxazolidin-3-yl]-4-oxobutanoate

: 1428741-21-2
(S)-2-((S)-(tert-butyldimethylsilyloxy)(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)methyl)-4-methoxy-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane / dichloromethane / 1 h / -45 °C / Inert atmosphere

1.2: 3 h / Inert atmosphere

2.1: dmap; 2,6-dimethylpyridine / dichloromethane / 16 h / 5 °C / Inert atmosphere

3.1: dihydrogen peroxide; lithium hydroxide monohydrate / tetrahydrofuran; water / 10 h / 0 - 30 °C / Inert atmosphere

With 2,6-dimethylpyridine; dmap; lithium hydroxide monohydrate; dihydrogen peroxide; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In tetrahydrofuran; dichloromethane; water; 1.1: |Aldol Condensation / 1.2: |Aldol Condensation;
DOI:10.1016/j.tetlet.2013.02.044

Reference yield:

: 1428741-15-4
C₂₅H₃₉NO₈Si

: 1428741-21-2
(S)-2-((S)-(tert-butyldimethylsilyloxy)(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)methyl)-4-methoxy-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 2,6-dimethylpyridine / dichloromethane / 16 h / 5 °C / Inert atmosphere

2: dihydrogen peroxide; lithium hydroxide monohydrate / tetrahydrofuran; water / 10 h / 0 - 30 °C / Inert atmosphere

With 2,6-dimethylpyridine; dmap; lithium hydroxide monohydrate; dihydrogen peroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tetlet.2013.02.044