(3S,4S)-methyl 4-(tert-butyldimethylsilyloxy)-4-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)butanoate

Base Information

Chemical Name:(3S,4S)-methyl 4-(tert-butyldimethylsilyloxy)-4-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)butanoate
CAS No.:1428741-17-6
Molecular Formula:C₃₁H₅₃NO₈Si₂
Molecular Weight:623.935
Hs Code.:

(3S,4S)-methyl 4-(tert-butyldimethylsilyloxy)-4-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)butanoate

Synonyms:(3S,4S)-methyl 4-(tert-butyldimethylsilyloxy)-4-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)butanoate

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Chemical Property of (3S,4S)-methyl 4-(tert-butyldimethylsilyloxy)-4-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)butanoate

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Technology Process of (3S,4S)-methyl 4-(tert-butyldimethylsilyloxy)-4-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)butanoate

There total 3 articles about (3S,4S)-methyl 4-(tert-butyldimethylsilyloxy)-4-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428741-15-4
C₂₅H₃₉NO₈Si

: 69739-34-0
t-butyldimethylsiyl triflate

: 1428741-17-6
(3S,4S)-methyl 4-(tert-butyldimethylsilyloxy)-4-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)butanoate

Guidance literature:: With 2,6-dimethylpyridine; dmap; In dichloromethane; at 5 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.02.044

Reference yield:

: 69404-94-0
O-tert-butyldimethylsilylvanillin

: 1428741-17-6
(3S,4S)-methyl 4-(tert-butyldimethylsilyloxy)-4-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane / dichloromethane / 1 h / -45 °C / Inert atmosphere

1.2: 3 h / Inert atmosphere

2.1: dmap; 2,6-dimethylpyridine / dichloromethane / 16 h / 5 °C / Inert atmosphere

With 2,6-dimethylpyridine; dmap; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In dichloromethane; 1.1: |Aldol Condensation / 1.2: |Aldol Condensation;
DOI:10.1016/j.tetlet.2013.02.044

Reference yield:

: methyl 4-[(S)-4-isopropyl-2-oxooxazolidin-3-yl]-4-oxobutanoate

: 1428741-17-6
(3S,4S)-methyl 4-(tert-butyldimethylsilyloxy)-4-(4-(tert-butyldimethylsilyloxy)-3-methoxyphenyl)-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane / dichloromethane / 1 h / -45 °C / Inert atmosphere

1.2: 3 h / Inert atmosphere

2.1: dmap; 2,6-dimethylpyridine / dichloromethane / 16 h / 5 °C / Inert atmosphere

With 2,6-dimethylpyridine; dmap; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In dichloromethane; 1.1: |Aldol Condensation / 1.2: |Aldol Condensation;
DOI:10.1016/j.tetlet.2013.02.044