2-[4-[(1,2-dihydro-8-methyl-2-oxoquinolin-4-yl)methoxy]phenylmethylene]-3-oxobutanoic acid ethyl ester

Base Information

• Chemical Name: 2-[4-[(1,2-dihydro-8-methyl-2-oxoquinolin-4-yl)methoxy]phenylmethylene]-3-oxobutanoic acid ethyl ester
• CAS No.: 1384968-65-3
• Molecular Formula: C₂₄H₂₃NO₅
• Molecular Weight: 405.45
• Mol file: 1384968-65-3.mol

Synonyms:2-[4-[(1,2-dihydro-8-methyl-2-oxoquinolin-4-yl)methoxy]phenylmethylene]-3-oxobutanoic acid ethyl ester

Chemical Property of 2-[4-[(1,2-dihydro-8-methyl-2-oxoquinolin-4-yl)methoxy]phenylmethylene]-3-oxobutanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-[(1,2-dihydro-8-methyl-2-oxoquinolin-4-yl)methoxy]phenylmethylene]-3-oxobutanoic acid ethyl ester

There total 5 articles about 2-[4-[(1,2-dihydro-8-methyl-2-oxoquinolin-4-yl)methoxy]phenylmethylene]-3-oxobutanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-[(1,2-dihydro-8-methyl-2-oxoquinolin-4-yl)methoxy]-benzaldehyde (1384968-49-3) + ethyl acetoacetate (141-97-9) → 2-[4-[(1,2-dihydro-8-methyl-2-oxoquinolin-4-yl)methoxy]phenylmethylene]-3-oxobutanoic acid ethyl ester (1384968-65-3)

Guidance literature:

With piperidine; In ethanol; at 20 ℃; for 6h;

DOI:10.1007/s00706-011-0692-2

Reference yield:

CH3C6H3NHCOCHCCH2Br (23976-56-9) + E-2-(4-Hydroxybenzyliden)acetessigsaeure-ethylester (58714-57-1) → 2-[4-[(1,2-dihydro-8-methyl-2-oxoquinolin-4-yl)methoxy]phenylmethylene]-3-oxobutanoic acid ethyl ester (1384968-65-3)

Guidance literature:

With potassium carbonate; In ethanol; at 100 ℃;

DOI:10.1007/s00706-011-0692-2

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 2-[4-[(1,2-dihydro-8-methyl-2-oxoquinolin-4-yl)methoxy]phenylmethylene]-3-oxobutanoic acid ethyl ester (1384968-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / ethanol

2: potassium carbonate / ethanol / 100 °C

With piperidine; potassium carbonate; In ethanol;

DOI:10.1007/s00706-011-0692-2

upstream raw materials:

CH₃C₆H₃NHCOCHCCH₂Br

E-2-(4-Hydroxybenzyliden)acetessigsaeure-ethylester

4-[(1,2-dihydro-8-methyl-2-oxoquinolin-4-yl)methoxy]-benzaldehyde

ethyl acetoacetate