58714-57-1

Upstream product

• 141-97-9 ethyl acetoacetate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 24405-45-6 ethyl 2-(4-methoxybenzylidene)-3-oxobutanoate 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1030295-97-6 Ethyl-2-[(4-hydroxy-2-oxo-2H-chromen-3-yl) (4-hydroxyphenyl)-methyl]-3-oxobutanoate 
• 1390630-46-2 (E)-ethyl 3-(3-bromo-4-hydroxyphenyl)-2-{[(tetrahydro-2H-pyran-2-yl)oxy]imino}propanoate 
• 1390630-45-1 C₁₃H₁₅BrO₄ 
• 109152-30-9 psammaplin A 
• 172854-02-3 (E)-ethyl 3-(3-bromo-4-hydroxyphenyl)-2-(hydroxyimino)propanoate 
• 52252-58-1 2-(4-Hydroxybenzyl)acetessigsaeure-ethylester 
• 1384968-62-0 2-[4-[(1,2-dihydro-2-oxoquinolin-4-yl)methoxy]phenylmethylene]-3-oxobutanoic acid ethyl ester 
• 1384968-65-3 2-[4-[(1,2-dihydro-8-methyl-2-oxoquinolin-4-yl)methoxy]phenylmethylene]-3-oxobutanoic acid ethyl ester 
• 1384968-64-2 2-[4-[(7-chloro-1,2-dihydro-2-oxoquinolin-4-yl)methoxy]phenylmethylene]-3-oxobutanoic acid ethyl ester 
• 1384968-63-1 2-[4-[(6-chloro-1,2-dihydro-2-oxoquinolin-4-yl)methoxy]phenylmethylene]-3-oxobutanoic acid ethyl ester 

Relevant academic research and scientific papers

All-natural carbon source raspberry ketone preparation method

The invention discloses an all-natural carbon source raspberry ketone preparation method, which comprises: carrying out a demethylation reaction on naturally-derived p-anisaldehyde as a raw material to prepare p-hydroxybenzaldehyde, carrying out a Knoevenagel condensation reaction on the p-hydroxybenzaldehyde and ethyl acetoacetate derived from biomass to obtain ethyl (E/Z)-2-acetyl-3-(4-hydroxyphenyl)acrylate, and carrying out hydrogenation, hydrolysis and decarboxylation to prepare the raspberry ketone. According to the present invention, the method can achieve the preparation of the all-natural carbon source raspberry ketone, and has advantages of simple route, easy operation, environmental friendliness, high yield and the like.

Synthesis of 3-Substituted coumarins: An efficient green approach using l-Proline as catalyst in triethanolamine medium

3-Substituted coumarins were synthesized very efficiently, using Knoevenagel method from salicylaldehydes 1 and active methylene compounds 2 under green conditions. The effect of catalyst and solvent on this condensation was studied. L-Proline was found t

Design and synthesis of 4-alkyl-2-amino(acetamino)-6-aryl-1,3-thiazine derivatives as influenza neuraminidase inhibitors

With a convenient and economical method, two series of 1,3-thiazine derivatives 1 and 2 were synthesized, and their neuraminidase (NA) inhibitory activities were evaluated. The pharmacological results showed that most of the compounds have potent NA inhibitory activity. Especially, 1g exhibited the best activity against influenza virus A (H1N1) NA (IC50 = 29.06 μg/mL), and its crystal structure was determined by single-crystal X-ray diffraction. The preliminary biological assay indicated that 1,3-thiazine could be used as a core structure to design novel influenza NA inhibitors. Two series of novel 1,3-thiazine analogs were synthesized and their neuraminidase (NA) inhibitory activities were evaluated. Most of the compounds have potent NA inhibitory activity. Compound 1g exhibited the best activity against influenza virus A (H1N1) NA with an IC50 of 29.06 μg/mL, and its crystal structure was determined by single-crystal X-ray diffraction.

Design, synthesis and computational validation of novel benzimidazole/indole-based PPARα and PPAR? partial agonists

The design and synthesis of benzimidazolyl and indolyl linked α-alkoxy phenylpropanoic acid derivatives and the β-keto ester analogues in an effort to develop novel peroxisome proliferator activated receptors ligands expected to exhibit PPARα and PPAR? pa

Efficient synthetic method of Psammaplin A

A new concise and efficient synthetic method of Psammaplin A was developed. Psammaplin A was obtained with 50% overall yield in nine steps from p-hydroxybenzaldehyde and ethyl acetoacetate via Knoevenagel condensation and direct nitrosation as key steps.

A facile synthesis of trisubstituted alkenes from β-diketones and aldehydes with AlCl3 as catalyst

Preparation of trisubstituted alkenes from low-activity β-diketones and aldehydes with aluminum chloride as catalyst has been studied. The frequently used catalyst AlCl3 is used for the first time to promote this condensation. The procedure is a convenient, low toxicity, and highly efficient method for industrial synthesis of trisubstituted alkenes in high yield. Springer Science+Business Media B.V. 2011.

Synthesis and biological studies of some new acrylic acid ethyl esters of quinolinone

A series of new acrylic acid ethyl esters of quinolinones were synthesized from 4-(bromomethyl)-quinolinones and screened for in vitro antimicrobial and in vivo analgesic and anti-inflammatory activities. Most of the compounds with chloro substitution at

Investigation of the antioxidant properties of some new 4-hydroxycoumarin derivatives

The aim of this investigation was to measure the activity of four 4-hydroxycoumarin derivatives - three of them were described before and one was newly synthesized. The substances were ethyl 2-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(4-hydroxyphenyl)methyl]-3-oxobutanoate (SS-14), 4-[1-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-(ethoxycarbonyl)-3-oxobutyl]benzoic acid (SS-17), ethyl 2-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(3-nitrophenyl)methyl]-3-oxobutanoate (SS-21) and ethyl 2-[(3,4,5-trimethoxyphenyl)(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-3-oxobutanoate (T-2). The synthesis of T-2 consists of two steps. First step was Knoevenagel reaction between 3,4,5-trimethoxybenzaldehyde and ethylacetoacetate. Ethyl 2-(3,4,5-trimethoxy)-phenylmethyleneacetoacetate was the product. Second step was Michael addition reaction between the latter product and 4-hydroxycoumarin. All the compounds were tested in vitro for antioxidant activity in hypochlorous system. The assay was based on the luminol-dependent chemiluminescence of free radicals, which decreased in the presence of 4-hydroxycoumarin derivative. Compound SS-14 (ethyl 2-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(4-hydroxyphenyl)methyl]-3-oxobutanoate) expresses the best scavenger activity at the highest concentration (10-4 mol/L).

Synthesis and biological evaluation of a novel series of 1,5-benzothiazepine derivatives as potential antimicrobial agents

Two series of novel 1,5-benzothiazepine derivatives (23 compounds) were efficiently synthesized and evaluated for antibacterial and antifungal activities. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed higher activity against fungi than bacteria. Compound 2e exhibited the greatest antimicrobial activity. Preliminary study of the structure-activity relationship revealed that substituents in phenyl rings had a great effect on the antimicrobial activity of these compounds.

Neat reaction technology for the synthesis of novel 1,5-benzodiazepines

A convenient, solvent-free, green approach is described for the synthesis of novel 1,5-benzodiazepines by the reaction of ethylacetoacetate, aldehyde, and o-phenylenediamine without any catalyst at pH 7. Copyright Taylor & Francis Group, LLC.