2-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-tetrahydro-pyran

Base Information

• Chemical Name: 2-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-tetrahydro-pyran
• CAS No.: 134052-28-1
• Molecular Formula: C₁₅H₂₈O₂
• Molecular Weight: 240.386
• Mol file: 134052-28-1.mol

Synonyms:2-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-tetrahydro-pyran

Chemical Property of 2-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-tetrahydro-pyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-tetrahydro-pyran

There total 5 articles about 2-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4-dihydro-2H-pyran (110-87-2) + menthol (89-78-1) → 2-(2-isopropyl-5-methylcyclohexyloxy)tetrahydro-2H-pyran (72020-06-5,80924-03-4,97526-56-2,123121-06-2,128946-28-1,128946-29-2,128946-30-5,128946-31-6,134052-28-1)

Guidance literature:

With lithium hexafluorophosphate; In hexane; at 10 - 15 ℃; for 0.25h;

DOI:10.1055/s-2004-829550

Reference yield: 98.0%

3,4-dihydro-2H-pyran (110-87-2) + (-)-menthol (2216-51-5) → 2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)tetrahydro-2H-pyran (72020-06-5,80924-03-4,97526-56-2,123121-06-2,128946-28-1,128946-29-2,128946-30-5,128946-31-6,134052-28-1)

Guidance literature:

With acetonyltriphenylphosphonium bromide; In dichloromethane; for 0.0833333h; Ambient temperature;

DOI:10.1016/S0040-4039(99)00274-9

Reference yield: 83.0%

(-)-menthol (2216-51-5) + 4,4,5,5-tetramethyl-2-(tetrahydro-2H-pyran-2-yl)-1,3,2-dioxaborolane → 2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)tetrahydro-2H-pyran (72020-06-5,80924-03-4,97526-56-2,123121-06-2,128946-28-1,128946-29-2,128946-30-5,128946-31-6,134052-28-1)

Guidance literature:

With [bis(acetoxy)iodo]benzene; manganese(II) acetate; copper(II) bis(trifluoromethanesulfonate); In chloroform; at 60 ℃; for 5h; Molecular sieve;

DOI:10.1021/acs.joc.0c00720

upstream raw materials:

3,4-dihydro-2H-pyran

(-)-menthol

menthol

Downstream raw materials:

(2R,5S)-menthone

L-menthyl acetate

menthyl formate

2-{[(tert-butyl)dimethylsilyl]oxy}-4-methyl-1-(1-methylethyl)cyclohexane