(S)-1-(3-Phenoxy-propyl)-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate

Base Information

Chemical Name:(S)-1-(3-Phenoxy-propyl)-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate
CAS No.:1196091-34-5
Molecular Formula:CHO₂*C₃₀H₄₀NO₃
Molecular Weight:507.67
Hs Code.:

Synonyms:(S)-1-(3-Phenoxy-propyl)-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate

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Chemical Property of (S)-1-(3-Phenoxy-propyl)-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate

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Technology Process of (S)-1-(3-Phenoxy-propyl)-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate

There total 9 articles about (S)-1-(3-Phenoxy-propyl)-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-18-6
formic acid

: 1196093-11-4
1-phenyl-cycloheptanecarboxylic acid (S)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

: 588-63-6
3-phenoxypropyl bromide

: 1196091-34-5
(S)-1-(3-Phenoxy-propyl)-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate

Guidance literature:: 1-phenyl-cycloheptanecarboxylic acid (S)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester; 3-phenoxypropyl bromide; In acetonitrile; at 20 - 50 ℃; for 144h;

formic acid; In water; acetonitrile; for 0.5h;

Reference yield:

: 502-42-1
cycloheptanone

: 1196091-34-5
(S)-1-(3-Phenoxy-propyl)-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate

Guidance literature:: Multi-step reaction with 6 steps

1.1: iodine; magnesium / tetrahydrofuran / 0.33 h / Inert atmosphere; Reflux

1.2: 0.17 h

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 60 °C

2.2: 60 °C / Reflux

3.1: potassium; sodium / diethyl ether / 20 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

3.3: pH 7

4.1: trimethylsilyldiazomethane / toluene / 0.75 h / Inert atmosphere

5.1: sodium hydride / toluene; mineral oil / 24 h / Inert atmosphere; Reflux

6.1: acetonitrile / 144 h / 20 - 50 °C

6.2: 0.5 h

With iodine; sodium; potassium; sodium hydride; magnesium; trimethylsilyldiazomethane; In tetrahydrofuran; diethyl ether; toluene; acetonitrile; mineral oil;

Reference yield:

: 6004-52-0
cycloheptyl(phenyl)methanone

: 1196091-34-5
(S)-1-(3-Phenoxy-propyl)-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane formate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuryl dichloride / 1 h / 0 °C

1.2: Reflux

2.1: water / silver nitrate / 1,4-dioxane / 4.5 h / 75 °C

3.1: trimethylsilyldiazomethane / toluene / 0.75 h / Inert atmosphere

4.1: sodium hydride / toluene; mineral oil / 24 h / Inert atmosphere; Reflux

5.1: acetonitrile / 144 h / 20 - 50 °C

5.2: 0.5 h

With sulfuryl dichloride; water; sodium hydride; trimethylsilyldiazomethane; silver nitrate; In 1,4-dioxane; toluene; acetonitrile; mineral oil;