methyl 1-phenylcycloheptanecarboxylate

Base Information

• Chemical Name: methyl 1-phenylcycloheptanecarboxylate
• CAS No.: 94163-02-7
• Molecular Formula: C₁₅H₂₀O₂
• Molecular Weight: 232.323
• Mol file: 94163-02-7.mol

Synonyms:methyl 1-phenylcycloheptanecarboxylate

Chemical Property of methyl 1-phenylcycloheptanecarboxylate

Chemical Property:

• Boiling Point: 321.0±21.0 °C(Predicted)
• Density: 1.035±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-phenylcycloheptanecarboxylate

There total 12 articles about methyl 1-phenylcycloheptanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methanol (67-56-1) + 1-methoxy-1-phenylcycloheptanol (32621-88-8) → methyl 1-phenylcycloheptanecarboxylate (94163-02-7)

Guidance literature:

With hydrogenchloride; In water; for 24h; Reflux;

DOI:10.1016/j.bmcl.2013.09.092

Reference yield:

bromobenzene (108-86-1,52753-63-6) + methyl cycloheptanecarboxylate (60433-00-3) → methyl 1-phenylcycloheptanecarboxylate (94163-02-7)

Guidance literature:

methyl cycloheptanecarboxylate; With n-butyllithium; N-cyclohexyl-cyclohexanamine; In hexane; toluene; at 20 ℃; for 0.0833333h; Inert atmosphere;

bromobenzene; With palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; In hexane; toluene; at 95 - 100 ℃; for 1h;

Reference yield:

1-phenyl-1-cycloheptanecarboxylic acid (7086-29-5) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 1-phenylcycloheptanecarboxylate (94163-02-7)

Guidance literature:

With methanol; In toluene; Inert atmosphere;

upstream raw materials:

methanol

1-phenyl-1-cycloheptanecarboxylic acid

diazomethyl-trimethyl-silane

cycloheptanone

Downstream raw materials:

1-phenyl-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester

(R)-3-(1-Phenyl-cycloheptanecarbonyloxy)-1-(pyridin-2-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane chloride

(R)-3-(1-Phenyl-cycloheptanecarbonyloxy)-1-(pyridin-2-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide

(R)-3-(1-Phenyl-cycloheptanecarbonyloxy)-1-(pyridin-4 ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane chloride

Refernces

• 1、 Mete, Antonio,Bowers, Keith,Bull, Richard J.,Coope, Helen,Donald, David K.,Escott, Katherine J.,Ford, Rhonan,Grime, Ken,Mather, Andrew,Ray, Nicholas C.,Russell, Vince. "The design of a novel series of muscarinic receptor antagonists leading to AZD8683, a potential inhaled treatment for COPD". . p. 6248 - 6253. Retrieved 2013/11/19.
• 2、 -. "QUINUCLIDINE DERIVATIVES AS MUSCARINIC M3 RECEPTOR ANTAGONISTS". Page/Page column 32-33. . Retrieved 2009/12/23.