tert-butyl 4-[2-(dimethylamino)ethyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[2-(dimethylamino)ethyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate
CAS No.:1192189-77-7
Molecular Formula:C₂₄H₃₈N₄O₅
Molecular Weight:462.59
Hs Code.:

Synonyms:tert-butyl 4-[2-(dimethylamino)ethyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[2-(dimethylamino)ethyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

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Technology Process of tert-butyl 4-[2-(dimethylamino)ethyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-[2-(dimethylamino)ethyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1192189-76-6
1-(tert-butoxycarbonyl)-4-[2-(dimethylamino)ethyl]piperidine-4-carboxylic acid

: 19962-04-0
Dimethylcarbaminsaeure-3-aminophenylester

: 1192189-77-7
tert-butyl 4-[2-(dimethylamino)ethyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

Guidance literature:: 1-(tert-butoxycarbonyl)-4-[2-(dimethylamino)ethyl]piperidine-4-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In Isopropyl acetate; for 10h; Inert atmosphere;

Dimethylcarbaminsaeure-3-aminophenylester; In Isopropyl acetate; at 85 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ml500367g

Reference yield:

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 1192189-77-7
tert-butyl 4-[2-(dimethylamino)ethyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate; water / ethanol / 60 °C / Inert atmosphere

2.2: 20 °C / pH 6 / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / Isopropyl acetate / 10 h / Inert atmosphere

3.2: 2 h / 85 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; Isopropyl acetate; cyclohexane;
DOI:10.1021/ml500367g

Reference yield:

: 1192189-75-5
1-tert-butyl 4-ethyl 4-[2-(dimethylamino)ethyl]piperidine-1,4-dicarboxylate

: 1192189-77-7
tert-butyl 4-[2-(dimethylamino)ethyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate; water / ethanol / 60 °C / Inert atmosphere

1.2: 20 °C / pH 6 / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / Isopropyl acetate / 10 h / Inert atmosphere

2.2: 2 h / 85 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethanol; Isopropyl acetate;
DOI:10.1021/ml500367g