1-benzoyl-2(S)-isopropyl-4-methoxy-6(S)-carbomethoxy-(1,2),(5,6)-tetrahydro-1,3-pyrimidine

Base Information

• Chemical Name: 1-benzoyl-2(S)-isopropyl-4-methoxy-6(S)-carbomethoxy-(1,2),(5,6)-tetrahydro-1,3-pyrimidine
• CAS No.: 211686-54-3
• Molecular Formula: C₁₇H₂₂N₂O₄
• Molecular Weight: 318.373
• Mol file: 211686-54-3.mol

Synonyms:1-benzoyl-2(S)-isopropyl-4-methoxy-6(S)-carbomethoxy-(1,2),(5,6)-tetrahydro-1,3-pyrimidine

Chemical Property of 1-benzoyl-2(S)-isopropyl-4-methoxy-6(S)-carbomethoxy-(1,2),(5,6)-tetrahydro-1,3-pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzoyl-2(S)-isopropyl-4-methoxy-6(S)-carbomethoxy-(1,2),(5,6)-tetrahydro-1,3-pyrimidine

There total 1 articles about 1-benzoyl-2(S)-isopropyl-4-methoxy-6(S)-carbomethoxy-(1,2),(5,6)-tetrahydro-1,3-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzoyl-2(S)-isopropyl-6(S)-carboxy-perhydropyrimidin-4-one (211686-52-1) + methyl iodide (74-88-4) → 1-benzoyl-2(S)-isopropyl-4-methoxy-6(S)-carbomethoxy-(1,2),(5,6)-tetrahydro-1,3-pyrimidine (211686-54-3)

Guidance literature:

With silver(l) oxide; Yield given. Multistep reaction; 1) THF, rt, 30 min; 2) THF, rt, 72 h;

DOI:10.1021/jo980367a

Reference yield: 90.0%

allyl bromide (106-95-6) + 1-benzoyl-2(S)-isopropyl-4-methoxy-6(S)-carbomethoxy-(1,2),(5,6)-tetrahydro-1,3-pyrimidine (211686-54-3) → 1-benzoyl-2(S)-isopropyl-4-methoxy-6(S)-carbomethoxy-6(S)-(2-propenyl)-(1,2),(5,6)-tetrahydro-1,3-pyrimidine

Guidance literature:

1-benzoyl-2(S)-isopropyl-4-methoxy-6(S)-carbomethoxy-(1,2),(5,6)-tetrahydro-1,3-pyrimidine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

allyl bromide; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/S0957-4166(99)00328-6

Reference yield: 58.0%

(E)-1-bromo-2-pentene (7348-71-2) + 1-benzoyl-2(S)-isopropyl-4-methoxy-6(S)-carbomethoxy-(1,2),(5,6)-tetrahydro-1,3-pyrimidine (211686-54-3) → 1-benzoyl-2(S)-isopropyl-4-methoxy-6(S)-carbomethoxy-6(S)-(2(E)-pentenyl)-(1,2),(5,6)-tetrahydro-1,3-pyrimidine

Guidance literature:

1-benzoyl-2(S)-isopropyl-4-methoxy-6(S)-carbomethoxy-(1,2),(5,6)-tetrahydro-1,3-pyrimidine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

(E)-1-bromo-2-pentene; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/S0957-4166(99)00328-6

upstream raw materials:

1-benzoyl-2(S)-isopropyl-6(S)-carboxy-perhydropyrimidin-4-one

methyl iodide

Downstream raw materials:

(2S,4S)-3-Benzoyl-4-butyl-2-isopropyl-6-methoxy-2,3,4,5-tetrahydro-pyrimidine-4-carboxylic acid methyl ester

(2S,4S)-3-Benzoyl-4-benzyl-2-isopropyl-6-methoxy-2,3,4,5-tetrahydro-pyrimidine-4-carboxylic acid methyl ester

(2S,4S)-3-Benzoyl-4-ethyl-2-isopropyl-6-methoxy-2,3,4,5-tetrahydro-pyrimidine-4-carboxylic acid methyl ester

(2S,4S)-3-Benzoyl-2-isopropyl-6-methoxy-4-methyl-2,3,4,5-tetrahydro-pyrimidine-4-carboxylic acid methyl ester