(R)-ethyl 3-(4-fluorophenyl)-2-hydroxy-2-(5-(methylsulfonamido)-1H-benzo[d]imidazol-2-yl)propanoate

Base Information

• Chemical Name: (R)-ethyl 3-(4-fluorophenyl)-2-hydroxy-2-(5-(methylsulfonamido)-1H-benzo[d]imidazol-2-yl)propanoate
• CAS No.: 1430200-31-9
• Molecular Formula: C₁₉H₂₀FN₃O₅S
• Molecular Weight: 421.449
• Mol file: 1430200-31-9.mol

Synonyms:(R)-ethyl 3-(4-fluorophenyl)-2-hydroxy-2-(5-(methylsulfonamido)-1H-benzo[d]imidazol-2-yl)propanoate

Chemical Property of (R)-ethyl 3-(4-fluorophenyl)-2-hydroxy-2-(5-(methylsulfonamido)-1H-benzo[d]imidazol-2-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-ethyl 3-(4-fluorophenyl)-2-hydroxy-2-(5-(methylsulfonamido)-1H-benzo[d]imidazol-2-yl)propanoate

There total 4 articles about (R)-ethyl 3-(4-fluorophenyl)-2-hydroxy-2-(5-(methylsulfonamido)-1H-benzo[d]imidazol-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-ethyl 3-(2-amino-4-(methylsulfonamido)phenylamino)-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoate (1430200-29-5) → (R)-ethyl 3-(4-fluorophenyl)-2-hydroxy-2-(5-(methylsulfonamido)-1H-benzo[d]imidazol-2-yl)propanoate (1430200-31-9)

Guidance literature:

With acetic acid; at 75 ℃; for 2h;

Reference yield:

N-(4-amino-3-nitrophenyl)methanesulphonamide (76345-45-4) → (R)-ethyl 3-(4-fluorophenyl)-2-hydroxy-2-(5-(methylsulfonamido)-1H-benzo[d]imidazol-2-yl)propanoate (1430200-31-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate; palladium 10% on activated carbon / methanol; ethyl acetate / 1 h

2: HATU / N,N-dimethyl-formamide / 20 °C

3: acetic acid / 2 h / 75 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; acetic acid; HATU; In methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

2-nitro-1,4-phenylenediamine (5307-14-2,183870-67-9) → (R)-ethyl 3-(4-fluorophenyl)-2-hydroxy-2-(5-(methylsulfonamido)-1H-benzo[d]imidazol-2-yl)propanoate (1430200-31-9)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 0.42 h / 70 °C / Reflux

2: sodium tetrahydroborate; palladium 10% on activated carbon / methanol; ethyl acetate / 1 h

3: HATU / N,N-dimethyl-formamide / 20 °C

4: acetic acid / 2 h / 75 °C

With pyridine; sodium tetrahydroborate; palladium 10% on activated carbon; acetic acid; HATU; In methanol; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

N-(4-amino-3-nitrophenyl)methanesulphonamide

2-nitro-1,4-phenylenediamine

N-(3,4-diaminophenyl)methanesulfonamide

(R)-ethyl 3-(2-amino-4-(methylsulfonamido)phenylamino)-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoate

Downstream raw materials:

C₂₅H₂₉FN₄O₅S