(R)-ethyl 3-(2-amino-4-(methylsulfonamido)phenylamino)-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoate

Base Information

• Chemical Name: (R)-ethyl 3-(2-amino-4-(methylsulfonamido)phenylamino)-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoate
• CAS No.: 1430200-29-5
• Molecular Formula: C₁₉H₂₂FN₃O₆S
• Molecular Weight: 439.465
• Mol file: 1430200-29-5.mol

Synonyms:(R)-ethyl 3-(2-amino-4-(methylsulfonamido)phenylamino)-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoate

Chemical Property of (R)-ethyl 3-(2-amino-4-(methylsulfonamido)phenylamino)-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-ethyl 3-(2-amino-4-(methylsulfonamido)phenylamino)-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoate

There total 3 articles about (R)-ethyl 3-(2-amino-4-(methylsulfonamido)phenylamino)-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-ethoxy-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoic acid (1430200-30-8) + N-(3,4-diaminophenyl)methanesulfonamide (76345-48-7) → (R)-ethyl 3-(2-amino-4-(methylsulfonamido)phenylamino)-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoate (1430200-29-5)

Guidance literature:

With HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

N-(4-amino-3-nitrophenyl)methanesulphonamide (76345-45-4) → (R)-ethyl 3-(2-amino-4-(methylsulfonamido)phenylamino)-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoate (1430200-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; palladium 10% on activated carbon / methanol; ethyl acetate / 1 h

2: HATU / N,N-dimethyl-formamide / 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; HATU; In methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

2-nitro-1,4-phenylenediamine (5307-14-2,183870-67-9) → (R)-ethyl 3-(2-amino-4-(methylsulfonamido)phenylamino)-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoate (1430200-29-5)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 0.42 h / 70 °C / Reflux

2: sodium tetrahydroborate; palladium 10% on activated carbon / methanol; ethyl acetate / 1 h

3: HATU / N,N-dimethyl-formamide / 20 °C

With pyridine; sodium tetrahydroborate; palladium 10% on activated carbon; HATU; In methanol; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

N-(4-amino-3-nitrophenyl)methanesulphonamide

2-nitro-1,4-phenylenediamine

(R)-3-ethoxy-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoic acid

N-(3,4-diaminophenyl)methanesulfonamide

Downstream raw materials:

(R)-ethyl 3-(4-fluorophenyl)-2-hydroxy-2-(5-(methylsulfonamido)-1H-benzo[d]imidazol-2-yl)propanoate

C₂₅H₂₉FN₄O₅S