3-Oxo-butyric acid (E)-4-(4-benzhydryl-piperazin-1-yl)-but-2-enyl ester

Base Information

Chemical Name:3-Oxo-butyric acid (E)-4-(4-benzhydryl-piperazin-1-yl)-but-2-enyl ester
CAS No.:121266-73-7
Molecular Formula:C₂₅H₃₀N₂O₃
Molecular Weight:406.525
Hs Code.:

Synonyms:3-Oxo-butyric acid (E)-4-(4-benzhydryl-piperazin-1-yl)-but-2-enyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Oxo-butyric acid (E)-4-(4-benzhydryl-piperazin-1-yl)-but-2-enyl ester

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Technology Process of 3-Oxo-butyric acid (E)-4-(4-benzhydryl-piperazin-1-yl)-but-2-enyl ester

There total 2 articles about 3-Oxo-butyric acid (E)-4-(4-benzhydryl-piperazin-1-yl)-but-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 674-82-8,2130-41-8
4-methyleneoxetan-2-one

: 121266-74-8
4-(4-benzhydryl-1-piperazinyl)-(E)-2-buten-1-ol

: 121266-73-7
3-Oxo-butyric acid (E)-4-(4-benzhydryl-piperazin-1-yl)-but-2-enyl ester

Guidance literature:: With dmap; In tetrahydrofuran; 1) ice-salt cooling, 30 min, 2) r.t.;
DOI:10.1248/cpb.39.91

Reference yield:

: 841-77-0
diphenylmethylpiperazine

: 121266-73-7
3-Oxo-butyric acid (E)-4-(4-benzhydryl-piperazin-1-yl)-but-2-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) methanesulfonyl chloride, Et₃N, 2) K₂CO₃ / 1) CH₂Cl₂, THF, r.t., 1.5h, 2) DMF, 65 - 70 deg C, 1h

2: 75 percent / DMAP / tetrahydrofuran / 1) ice-salt cooling, 30 min, 2) r.t.

With dmap; potassium carbonate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1248/cpb.39.91