(-)-(R)-4-benzyl-3-((2R,3S)-3-hydroxy-2,4-dimethylpentanoyl)oxazolidin-2-one

Base Information

Chemical Name:(-)-(R)-4-benzyl-3-((2R,3S)-3-hydroxy-2,4-dimethylpentanoyl)oxazolidin-2-one
CAS No.:189069-42-9
Molecular Formula:C₁₇H₂₃NO₄
Molecular Weight:305.374
Hs Code.:

Synonyms:(-)-(R)-4-benzyl-3-((2R,3S)-3-hydroxy-2,4-dimethylpentanoyl)oxazolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-(R)-4-benzyl-3-((2R,3S)-3-hydroxy-2,4-dimethylpentanoyl)oxazolidin-2-one

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Technology Process of (-)-(R)-4-benzyl-3-((2R,3S)-3-hydroxy-2,4-dimethylpentanoyl)oxazolidin-2-one

There total 8 articles about (-)-(R)-4-benzyl-3-((2R,3S)-3-hydroxy-2,4-dimethylpentanoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 101711-78-8,131685-53-5
(3R)-3-propionyl-4-benzyloxazolidin-2-one

: 78-84-2
isobutyraldehyde

: 189069-42-9
(-)-(R)-4-benzyl-3-((2R,3S)-3-hydroxy-2,4-dimethylpentanoyl)oxazolidin-2-one

Guidance literature:: (3R)-3-propionyl-4-benzyloxazolidin-2-one; With di-n-butylboryl trifluoromethanesulfonate; triethylamine; In dichloromethane; for 0.166667h;

isobutyraldehyde; In dichloromethane; at -78 - 0 ℃;
DOI:10.1021/ja027638q

Reference yield: 77.0%

: 101711-78-8,131685-53-5
(3R)-3-propionyl-4-benzyloxazolidin-2-one

: 590-86-3
isovaleraldehyde

: 189069-42-9
(-)-(R)-4-benzyl-3-((2R,3S)-3-hydroxy-2,4-dimethylpentanoyl)oxazolidin-2-one

Guidance literature:: (3R)-3-propionyl-4-benzyloxazolidin-2-one; With di-n-butylboryl trifluoromethanesulfonate; triethylamine; In dichloromethane; at -78 - 2 ℃; Inert atmosphere;

isovaleraldehyde; In dichloromethane; at -78 - -10 ℃; for 2h; Inert atmosphere;
DOI:10.1002/anie.201402255

Reference yield:

: 101711-78-8,131685-53-5
(3R)-3-propionyl-4-benzyloxazolidin-2-one

: 189069-42-9
(-)-(R)-4-benzyl-3-((2R,3S)-3-hydroxy-2,4-dimethylpentanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / -10 °C / Inert atmosphere

2: -78 - 0 °C / Inert atmosphere

With triethylamine; In dichloromethane; 2: |Aldol Addition;
DOI:10.1021/acs.joc.7b00023