2-(dimethylamino)-2-phenylacetic acid (hydrochloride salt)

Base Information

• Chemical Name: 2-(dimethylamino)-2-phenylacetic acid (hydrochloride salt)
• CAS No.: 58685-78-2
• Molecular Formula: C₁₀H₁₃NO₂*ClH
• Molecular Weight: 215.68
• Mol file: 58685-78-2.mol

Synonyms:2-(dimethylamino)-2-phenylacetic acid (hydrochloride salt)

Chemical Property of 2-(dimethylamino)-2-phenylacetic acid (hydrochloride salt)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(dimethylamino)-2-phenylacetic acid (hydrochloride salt)

There total 3 articles about 2-(dimethylamino)-2-phenylacetic acid (hydrochloride salt) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl α-N,N-dimethylphenyl acetate (6319-70-6) → 2-(dimethylamino)-2-phenylacetic acid (hydrochloride salt) (58685-78-2,1353887-53-2)

Guidance literature:

With hydrogenchloride; In water; at 120 ℃; for 2h; Sealed; Microwave irradiation;

Reference yield: 78.3%

2-bromophenylacetic acid (4870-65-9,31302-84-8) + dimethyl amine (124-40-3) → 2-(dimethylamino)-2-phenylacetic acid (hydrochloride salt) (58685-78-2,1353887-53-2)

Guidance literature:

2-bromophenylacetic acid; dimethyl amine; In acetone; at 5 - 20 ℃; for 1h;

With hydrogenchloride; pH=3 - 4;

Reference yield:

N,N-dimethylbenzamide (611-74-5) → 2-(dimethylamino)-2-phenylacetic acid (hydrochloride salt) (58685-78-2,1353887-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bis(triphenylphosphine)iridium(I) carbonyl chloride / toluene / 0.08 h / 20 °C

1.2: 0.08 h / 20 °C

1.3: 0.5 h / 20 °C

2.1: hydrogenchloride / dichloromethane; water / 24 h / Reflux

With hydrogenchloride; bis(triphenylphosphine)iridium(I) carbonyl chloride; In dichloromethane; water; toluene;

DOI:10.1002/anie.201612367

upstream raw materials:

ethyl α-N,N-dimethylphenyl acetate

N,N-dimethylbenzamide

2-bromophenylacetic acid

dimethyl amine