Technology Process of 2-Carboxy-5,5-dimethyl-1,3-dioxane
There total 1 articles about 2-Carboxy-5,5-dimethyl-1,3-dioxane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,2-Dimethyl-1,3-propanediol; Glyoxilic acid;
With
amberlyst-15;
In
benzene;
for 15h;
Heating;
With
sodium hydroxide;
In
water;
for 0.5h;
Heating;
DOI:10.1021/jo049819b
- Guidance literature:
-
With
dipotassium hydrogenphosphate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 12h;
Inert atmosphere;
Schlenk technique;
Irradiation;
DOI:10.1039/c7cc06252d
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triphenylphosphine / tetrahydrofuran / 24 h / 20 °C
2: 732 mg / EtMgBr / tetrahydrofuran / -78 - 20 °C
With
ethylmagnesium bromide; triphenylphosphine;
In
tetrahydrofuran;
1: Mukaiyama reaction;
DOI:10.1021/jo049819b
