<3S-(3α,3β,4β)>-1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-benzazepin-2-one

Base Information

Chemical Name:<3S-(3α,3β,4β)>-1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-benzazepin-2-one
CAS No.:138663-28-2
Molecular Formula:C₂₁H₂₀F₃NO₄
Molecular Weight:407.389
Hs Code.:

Synonyms:<3S-(3α,3β,4β)>-1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-benzazepin-2-one

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Chemical Property of <3S-(3α,3β,4β)>-1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-benzazepin-2-one

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Technology Process of <3S-(3α,3β,4β)>-1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-benzazepin-2-one

There total 11 articles about <3S-(3α,3β,4β)>-1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 138573-41-8
2-[2-(2-Amino-6-trifluoromethyl-phenyl)-1-(4-methoxy-phenyl)-ethyl]-2-methyl-malonic acid dimethyl ester

: 111605-18-6,119252-06-1,138573-55-4,138663-28-2
(3S,4R)-4-(4-Methoxy-phenyl)-3-methyl-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-3-carboxylic acid methyl ester

Guidance literature:: With sodium methylate; In methanol; N,N-dimethyl-formamide; at 95 ℃;
DOI:10.1021/jm00082a019

Reference yield: 40.0%

: 111605-17-5,119217-53-7
<3S-(3α,3β,4β)>-1,3,4,5-tetrahydro-3-(methoxycarbonyl)-1-(methoxymethyl)-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-benzazepin-2-one

: 138663-28-2
<3S-(3α,3β,4β)>-1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-benzazepin-2-one

Guidance literature:: With sulfuric acid; lithium bromide; In methanol; for 4h; Heating;
DOI:10.1021/jm00082a019

Reference yield:

: 6656-49-1
2-methyl-1-nitro-3-(trifluoromethyl)benzene

: 111605-18-6,119252-06-1,138573-55-4,138663-28-2
(3S,4S)-4-(4-Methoxy-phenyl)-3-methyl-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / dimethylformamide / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 4 h

3: H₂ / 10percent Pd/C / acetonitrile / 4 h / 2068.6 Torr

4: MeONa / methanol / 3 h / Heating

With hydrogen; sodium methylate; sodium hydride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00082a020