17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(benzyloxy)-4,5α-epoxy-14-dihydroxymorphinan

Base Information

• Chemical Name: 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(benzyloxy)-4,5α-epoxy-14-dihydroxymorphinan
• CAS No.: 159465-48-2
• Molecular Formula: C₄₆H₄₅NO₄
• Molecular Weight: 675.868
• Mol file: 159465-48-2.mol

Synonyms:17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(benzyloxy)-4,5α-epoxy-14-dihydroxymorphinan

Chemical Property of 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(benzyloxy)-4,5α-epoxy-14-dihydroxymorphinan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(benzyloxy)-4,5α-epoxy-14-dihydroxymorphinan

There total 3 articles about 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(benzyloxy)-4,5α-epoxy-14-dihydroxymorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

benzyl bromide (100-39-0) + 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-4,5α-epoxy-6β,14-dihydroxymorphinan (159465-47-1) → 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(benzyloxy)-4,5α-epoxy-14-dihydroxymorphinan (159465-48-2)

Guidance literature:

With potassium hydroxide; tetrabutylammomium bromide; In dichloromethane;

Reference yield:

β-naltrexol (49625-89-0) → 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(benzyloxy)-4,5α-epoxy-14-dihydroxymorphinan (159465-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / TBAHSO₄, aq. KOH / CH₂Cl₂ / Ambient temperature

2: 78 percent / TBABr, 50percent aq. KOH / CH₂Cl₂

With potassium hydroxide; tetrabutylammomium bromide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane;

Reference yield:

trityl chloride (76-83-5) → 17-(cyclopropylmethyl)-3-(triphenylmethoxy)-6β-(benzyloxy)-4,5α-epoxy-14-dihydroxymorphinan (159465-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / TBAHSO₄, aq. KOH / CH₂Cl₂ / Ambient temperature

2: 78 percent / TBABr, 50percent aq. KOH / CH₂Cl₂

With potassium hydroxide; tetrabutylammomium bromide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane;

upstream raw materials:

benzyl bromide

17-(cyclopropylmethyl)-3-(triphenylmethoxy)-4,5α-epoxy-6β,14-dihydroxymorphinan

β-naltrexol

trityl chloride