(R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Base Information

Chemical Name:(R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester
CAS No.:111042-80-9
Molecular Formula:C₂₈H₄₈O₃Si
Molecular Weight:460.773
Hs Code.:

Synonyms:(R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

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Chemical Property of (R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

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Technology Process of (R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

There total 5 articles about (R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 111042-70-7
(1R,3R,4S)-8-phenyl-p-menthan-3-yl (2R)-2-hydroxymethyl-3-methylbutyrate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 111042-80-9
(R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide; for 10h; Ambient temperature;

Reference yield:

: 601-79-6
isopropylmalonic acid

: 111042-80-9
(R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / dicyclohexylcarbodi-imide, 4-(N,N-dimethylamino)pyridine / acetonitrile; CH₂Cl₂ / -30 deg,C, 16 h; 18 deg C, 8 h

2: 100 percent / dicyclohexylcarbodi-imide, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 15 h / Ambient temperature

3: sodium borohydride / tetrahydrofuran / 1 h / Ambient temperature

4: 99 percent / 4-(N,N-dimethylamino)pyridine, triethylamine / CH₂Cl₂; dimethylformamide / 10 h / Ambient temperature

With dmap; sodium tetrahydroborate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 65253-04-5
(-)-8-phenylmenthol

: 111042-80-9
(R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / dicyclohexylcarbodi-imide, 4-(N,N-dimethylamino)pyridine / acetonitrile; CH₂Cl₂ / -30 deg,C, 16 h; 18 deg C, 8 h

2: 100 percent / dicyclohexylcarbodi-imide, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 15 h / Ambient temperature

3: sodium borohydride / tetrahydrofuran / 1 h / Ambient temperature

4: 99 percent / 4-(N,N-dimethylamino)pyridine, triethylamine / CH₂Cl₂; dimethylformamide / 10 h / Ambient temperature

With dmap; sodium tetrahydroborate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;