2-[(7-benzyloxycarbonyl-7-aza-bicyclo[2.2.1]heptane-1-carboximidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester

Base Information

Chemical Name:2-[(7-benzyloxycarbonyl-7-aza-bicyclo[2.2.1]heptane-1-carboximidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester
CAS No.:519031-97-1
Molecular Formula:C₂₁H₂₅N₃O₇
Molecular Weight:431.445
Hs Code.:

Synonyms:2-[(7-benzyloxycarbonyl-7-aza-bicyclo[2.2.1]heptane-1-carboximidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester

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Chemical Property of 2-[(7-benzyloxycarbonyl-7-aza-bicyclo[2.2.1]heptane-1-carboximidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester

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Technology Process of 2-[(7-benzyloxycarbonyl-7-aza-bicyclo[2.2.1]heptane-1-carboximidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester

There total 4 articles about 2-[(7-benzyloxycarbonyl-7-aza-bicyclo[2.2.1]heptane-1-carboximidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 519031-96-0
benzyl 1-cyano-7-azabicyclo[2.2.1]heptane-7-carboxylate

: 519031-97-1
2-[(7-benzyloxycarbonyl-7-aza-bicyclo[2.2.1]heptane-1-carboximidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NH₂OH / methanol / 60 °C

2: CHCl₃ / 5 h / Heating

With hydroxylamine; In methanol; chloroform;
DOI:10.1021/jm070027u

Reference yield:

: 519031-95-9
1-carbamoyl-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester

: 519031-97-1
2-[(7-benzyloxycarbonyl-7-aza-bicyclo[2.2.1]heptane-1-carboximidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N; trifluoroacetic anhydride / CH₂Cl₂ / 3.5 h / 20 °C

2: NH₂OH / methanol / 60 °C

3: CHCl₃ / 5 h / Heating

With hydroxylamine; triethylamine; trifluoroacetic anhydride; In methanol; dichloromethane; chloroform;
DOI:10.1021/jm070027u

Reference yield:

: 182137-60-6
7-[(benzyloxy)carbonyl]-7-azabicyclo[2.2.1]heptane-1-carboxylic acid

: 519031-97-1
2-[(7-benzyloxycarbonyl-7-aza-bicyclo[2.2.1]heptane-1-carboximidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: di-tert-butyl dicarbonate; NH₄HCO₃; pyridine / dioxane / 20 h / 20 °C

2: Et₃N; trifluoroacetic anhydride / CH₂Cl₂ / 3.5 h / 20 °C

3: NH₂OH / methanol / 60 °C

4: CHCl₃ / 5 h / Heating

With pyridine; di-tert-butyl dicarbonate; hydroxylamine; ammonium bicarbonate; triethylamine; trifluoroacetic anhydride; In 1,4-dioxane; methanol; dichloromethane; chloroform;
DOI:10.1021/jm070027u