N-(benzylsulfonyl)-1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)piperidine-4-carboxamide

Base Information

Chemical Name:N-(benzylsulfonyl)-1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)piperidine-4-carboxamide
CAS No.:1204588-56-6
Molecular Formula:C₂₄H₂₈N₄O₄S
Molecular Weight:468.577
Hs Code.:

Synonyms:N-(benzylsulfonyl)-1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)piperidine-4-carboxamide

Suppliers and Price of N-(benzylsulfonyl)-1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)piperidine-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(benzylsulfonyl)-1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)piperidine-4-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(benzylsulfonyl)-1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)piperidine-4-carboxamide

There total 7 articles about N-(benzylsulfonyl)-1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₁ClN₄O₄S

: 927-77-5
n-propylmagnesium bromide

: 1204588-56-6
N-(benzylsulfonyl)-1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)piperidine-4-carboxamide

Guidance literature:: C₂₁H₂₁ClN₄O₄S; n-propylmagnesium bromide; iron(III)-acetylacetonate; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

With hydrogenchloride; water; In dichloromethane;

Reference yield:

: 1204588-78-2
tert-butyl 1-[5-(chlorocarbonyl)-3-cyano-6-methylpyridin-2-yl]piperidine-4-carboxylate

: 1204588-56-6
N-(benzylsulfonyl)-1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron(III)-acetylacetonate / tetrahydrofuran / 0 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane

With iron(III)-acetylacetonate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2014.04.001

Reference yield:

: 64119-42-2
ethyl 6-chloro-5-cyano-2-methylnicotinate

: 1204588-56-6
N-(benzylsulfonyl)-1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / acetonitrile / 0.08 h / 100 °C / Microwave irradiation

2: sodium hydroxide; water / 80 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.33 h / 0 - 20 °C

4: iron(III)-acetylacetonate / tetrahydrofuran / 0 °C

5: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane

With oxalyl dichloride; iron(III)-acetylacetonate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2014.04.001