42-O-[((R)-3-hydroxypyrrolidin-1-yl)acetyl]-31-O-trimethylsilyl-rapamycin

Base Information

Chemical Name:42-O-[((R)-3-hydroxypyrrolidin-1-yl)acetyl]-31-O-trimethylsilyl-rapamycin
CAS No.:1192722-03-4
Molecular Formula:C₆₀H₉₆N₂O₁₅Si
Molecular Weight:1113.51
Hs Code.:

Synonyms:42-O-[((R)-3-hydroxypyrrolidin-1-yl)acetyl]-31-O-trimethylsilyl-rapamycin

Suppliers and Price of 42-O-[((R)-3-hydroxypyrrolidin-1-yl)acetyl]-31-O-trimethylsilyl-rapamycin

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Chemical Property of 42-O-[((R)-3-hydroxypyrrolidin-1-yl)acetyl]-31-O-trimethylsilyl-rapamycin

Chemical Property:

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Technology Process of 42-O-[((R)-3-hydroxypyrrolidin-1-yl)acetyl]-31-O-trimethylsilyl-rapamycin

There total 3 articles about 42-O-[((R)-3-hydroxypyrrolidin-1-yl)acetyl]-31-O-trimethylsilyl-rapamycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111810-68-5
(R)-3-hydroxypyrrolidine hydrochloride

: 1192722-01-2
42-O-(2-bromoacetyl)-31-O-trimethylsilyl-rapamycin

: 1192722-03-4
42-O-[((R)-3-hydroxypyrrolidin-1-yl)acetyl]-31-O-trimethylsilyl-rapamycin

Guidance literature:: (R)-3-hydroxypyrrolidine hydrochloride; 42-O-(2-bromoacetyl)-31-O-trimethylsilyl-rapamycin; With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 6h;

tetrabutylammonium sulfate; In N,N-dimethyl-formamide; at 40 ℃; for 8h;

Reference yield:

: 331810-10-7
31-(trimethylsilylether)rapamycin

: 1192722-03-4
42-O-[((R)-3-hydroxypyrrolidin-1-yl)acetyl]-31-O-trimethylsilyl-rapamycin

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 6 h / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 40 °C

2.2: 8 h / 40 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 53123-88-9
sirolimus

: 1192722-03-4
42-O-[((R)-3-hydroxypyrrolidin-1-yl)acetyl]-31-O-trimethylsilyl-rapamycin

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / ethyl acetate / 0.5 h / 20 °C

1.2: 1.5 h / 0 °C

2.1: triethylamine / dichloromethane / 6 h / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 40 °C

3.2: 8 h / 40 °C

With 1H-imidazole; potassium carbonate; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;