31-(trimethylsilylether)rapamycin

Base Information

Chemical Name:31-(trimethylsilylether)rapamycin
CAS No.:331810-10-7
Molecular Formula:C₅₄H₈₇NO₁₃Si
Molecular Weight:986.369
Hs Code.:

Synonyms:31-(trimethylsilylether)rapamycin

Suppliers and Price of 31-(trimethylsilylether)rapamycin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 31-(trimethylsilylether)rapamycin

Chemical Property:

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Technology Process of 31-(trimethylsilylether)rapamycin

There total 3 articles about 31-(trimethylsilylether)rapamycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 75-77-4
chloro-trimethyl-silane

: 53123-88-9
sirolimus

: 331810-10-7
31-(trimethylsilylether)rapamycin

Guidance literature:: With 1H-imidazole; In ethyl acetate; at 0 - 5 ℃; for 2h;

Reference yield: 92.9%

: 331810-13-0
31,42-bis(trimethylsilylether)rapamycin

: 331810-10-7
31-(trimethylsilylether)rapamycin

Guidance literature:: With hydrogenchloride; water; In ethyl acetate; at 0 - 10 ℃; Temperature; Inert atmosphere;

Reference yield:

: 53123-88-9
sirolimus

: 331810-10-7
31-(trimethylsilylether)rapamycin

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / ethyl acetate / 0.5 h / 0 °C

2: sulfuric acid / water; ethyl acetate / 3 h / 0 °C

With 1H-imidazole; sulfuric acid; In water; ethyl acetate;
DOI:10.3390/molecules19067770