N-(5,6-dimethylbenzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyri midine-5-carboxamide

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Chemical Name:N-(5,6-dimethylbenzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyri midine-5-carboxamide
CAS No.:1437792-34-1
Molecular Formula:C₃₁H₂₇N₅O₄S
Molecular Weight:565.652
Hs Code.:

Synonyms:N-(5,6-dimethylbenzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyri midine-5-carboxamide

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Chemical Property of N-(5,6-dimethylbenzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyri midine-5-carboxamide

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Technology Process of N-(5,6-dimethylbenzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyri midine-5-carboxamide

There total 4 articles about N-(5,6-dimethylbenzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyri midine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 29927-08-0
2-amino-5,6-dimethylbenzothiazole

: 1397213-22-7
2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-5-carboxylic acid

: 1437792-34-1
N-(5,6-dimethylbenzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyri midine-5-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 8.16667h;
DOI:10.1016/j.bmcl.2013.03.129

Reference yield:

: 1136-86-3
methyl (3,4,5-trimethoxyphenyl) ketone

: 1437792-34-1
N-(5,6-dimethylbenzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyri midine-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / tetrahydrofuran / 8 h / 20 °C

2: hydrogenchloride / ethanol / 2 h / Reflux

3: sodium hydroxide / methanol / 2 h / Reflux

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 8.17 h / 0 - 20 °C

With hydrogenchloride; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2013.03.129

Reference yield:

: 70311-74-9
methyl 2,4-dioxo-4-(3,4,5-trimethoxyphenyl)butanoate

: 1437792-34-1
N-(5,6-dimethylbenzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyri midine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol / 2 h / Reflux

2: sodium hydroxide / methanol / 2 h / Reflux

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 8.17 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2013.03.129