1-(4-(3-(methylamino)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutanamine

Base Information

Chemical Name:1-(4-(3-(methylamino)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutanamine
CAS No.:1313438-43-5
Molecular Formula:C₂₇H₂₇N₅
Molecular Weight:421.545
Hs Code.:

Synonyms:1-(4-(3-(methylamino)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutanamine

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Chemical Property of 1-(4-(3-(methylamino)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutanamine

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Technology Process of 1-(4-(3-(methylamino)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutanamine

There total 5 articles about 1-(4-(3-(methylamino)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1313440-00-4
tert-butyl (1-(4-(3-(methylamino)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutyl)carbamate

: 1313438-43-5
1-(4-(3-(methylamino)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutanamine

Guidance literature:: With trifluoroacetic acid; for 0.00833333h;

Reference yield:

: 1032349-98-6
tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1313438-43-5
1-(4-(3-(methylamino)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 18 h / 80 °C / Inert atmosphere

2.1: acetic acid / 2 h / 100 °C / Inert atmosphere; Molecular sieve

3.1: potassium tert-butylate / tetrahydrofuran / 0.42 h / 20 °C / Inert atmosphere

3.2: 0.58 h / 20 °C / Inert atmosphere

3.3: 1.5 h / 20 °C

4.1: ethanol; tetrahydrofuran / 4 h / 80 °C / Inert atmosphere

4.2: 18 h / 80 °C

5.1: trifluoroacetic acid / 0.01 h

With potassium tert-butylate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; ethanol;

Reference yield:

: 1313439-93-8
tert-butyl (1-(4-(6-(bis(methylthio)methylene)-5-oxo-3-phenyl-5,6,7,8-tetrahydroquinolin-2-yl)phenyl)cyclobutyl)carbamate

: 1313438-43-5
1-(4-(3-(methylamino)-8-phenyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinolin-7-yl)phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol; tetrahydrofuran / 4 h / 80 °C / Inert atmosphere

1.2: 18 h / 80 °C

2.1: trifluoroacetic acid / 0.01 h

With trifluoroacetic acid; In tetrahydrofuran; ethanol;