3-benzoyl-8-chloro-1,2-dihydro-4H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-trione

Base Information

• Chemical Name: 3-benzoyl-8-chloro-1,2-dihydro-4H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-trione
• CAS No.: 887761-84-4
• Molecular Formula: C₁₈H₈ClNO₅
• Molecular Weight: 353.718

Synonyms:3-benzoyl-8-chloro-1,2-dihydro-4H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-trione

Chemical Property of 3-benzoyl-8-chloro-1,2-dihydro-4H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-trione

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Technology Process of 3-benzoyl-8-chloro-1,2-dihydro-4H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-trione

There total 6 articles about 3-benzoyl-8-chloro-1,2-dihydro-4H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(Z)-6-chloro-3-(2-oxo-2-phenylethylidene)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-one (32781-14-9) + oxalyl dichloride (79-37-8) → 3-benzoyl-8-chloro-1,2-dihydro-4H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-trione (887761-84-4)

Guidance literature:

In benzene; Reflux;

DOI:10.1134/S1070428011060182

Reference yield: 52.0%

(Z)-6-chloro-3-(2-oxo-2-phenylethylidene)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-one (32781-14-9) + oxalyl dichloride (79-37-8) → 3-benzoyl-8-chloro-1,2-dihydro-4H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-trione (887761-84-4) + 3-benzoyl-2,3a-dihydroxy-8-chloro-1,3a-dihydro-4H-pyrrolo[2,1-c][1,4]benzoxazine-1,4-dione

Guidance literature:

In dichloromethane; chloroform; for 2h; Heating;

DOI:10.1007/s11178-005-0321-9

Reference yield:

(2aS*,3R*,5aS*)-2a-benzoyl-10-chloro-3,4-diphenyl-3,4-dihydro-1H,6H-benzo[b]isoxazolo[5',4':2,3]pyrrolo[1,2-d][1,4]oxazine-1,2,6(2aH)-trione → 3-benzoyl-8-chloro-1,2-dihydro-4H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-trione (887761-84-4) + N-(benzylidene)aniline N-oxide (1137-96-8,26505-49-7,201024-81-9)

Guidance literature:

In acetonitrile; at 25 ℃; for 24h; Solvent; Time; Sealed tube;

DOI:10.1016/j.tetlet.2020.151595

upstream raw materials:

(Z)-6-chloro-3-(2-oxo-2-phenylethylidene)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-one

oxalyl dichloride

(Z)-methyl 2-hydroxy-4-oxo-4-phenylbut-2-enoate

2-hydroxy-5-chloro-aniline

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