Technology Process of N-(4-(3-chlorophenyl)thiophen-2-yl)-2-(4-(ethylsulfonyl)phenyl)propanamide
There total 9 articles about N-(4-(3-chlorophenyl)thiophen-2-yl)-2-(4-(ethylsulfonyl)phenyl)propanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
Inert atmosphere;
Reflux;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C
2.1: hydrogenchloride; sodium nitrite / water / 0 °C
2.2: 20 - 45 °C
2.3: 20 °C / pH 1
3.1: water; potassium hydroxide / ethanol / 3 h / Reflux
3.2: Cooling with ice
4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
6.1: water; sodium hydroxide / ethanol / 20 °C
6.2: pH 1
7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / Inert atmosphere; Reflux
With
hydrogenchloride; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; sodium hydroxide; sodium nitrite;
palladium 10% on activated carbon;
In
methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: morpholine; sulfur / ethanol / Reflux
2.1: ethanol; potassium hydroxide / 20 h / Reflux
2.2: pH 7
3.1: hydrogenchloride / ethanol; water / 2 h / 20 °C
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / Inert atmosphere; Reflux
With
morpholine; hydrogenchloride; ethanol; benzotriazol-1-ol; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
In
ethanol; dichloromethane; water;
