3-(ethoxycarbonyl)-5-(pentafluorophenyl)-1,2,4-oxadiazole

Base Information

• Chemical Name: 3-(ethoxycarbonyl)-5-(pentafluorophenyl)-1,2,4-oxadiazole
• CAS No.: 1251535-87-1
• Molecular Formula: C₁₁H₅F₅N₂O₃
• Molecular Weight: 308.164
• Mol file: 1251535-87-1.mol

Synonyms:3-(ethoxycarbonyl)-5-(pentafluorophenyl)-1,2,4-oxadiazole

Chemical Property of 3-(ethoxycarbonyl)-5-(pentafluorophenyl)-1,2,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(ethoxycarbonyl)-5-(pentafluorophenyl)-1,2,4-oxadiazole

There total 1 articles about 3-(ethoxycarbonyl)-5-(pentafluorophenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

O-pentafluorobenzoylcarboxyethylamidoxime (1329090-04-1) → 3-(ethoxycarbonyl)-5-(pentafluorophenyl)-1,2,4-oxadiazole (1251535-87-1)

Guidance literature:

at 180 ℃; for 1h; Neat (no solvent);

DOI:10.1002/ejoc.201000763

Reference yield: 95.0%

3-(ethoxycarbonyl)-5-(pentafluorophenyl)-1,2,4-oxadiazole (1251535-87-1) + methylamine (74-89-5) → 5-[2,3,5,6-tetrafluoro-4-(N-methylamino)-phenyl]3-carboxyethyl-1,2,4-oxadiazole (1251535-94-0)

Guidance literature:

With potassium carbonate; In ethanol; N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1002/ejoc.201000763

Reference yield: 80.0%

morpholine (110-91-8,99108-56-2) + 3-(ethoxycarbonyl)-5-(pentafluorophenyl)-1,2,4-oxadiazole (1251535-87-1) → 3-(ethoxycarbonyl)-5-(2',3',5',6'-tetrafluoro-4'-(morpholin-N-yl)phenyl)-1,2,4-oxadiazole (1370025-81-2)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1016/j.ejmech.2012.02.002

upstream raw materials:

O-pentafluorobenzoylcarboxyethylamidoxime

Downstream raw materials:

C₃₉H₃₀F₁₂N₁₀O₉

C₃₉H₃₀F₁₂N₁₀O₉

5-[2,3,5,6-tetrafluoro-4-(N-methylamino)-phenyl]3-carboxyethyl-1,2,4-oxadiazole

3-(ethoxycarbonyl)-5-(2',3',5',6'-tetrafluoro-4'-(morpholin-N-yl)phenyl)-1,2,4-oxadiazole