3,6-anhydro-1,2-dideoxy-4,5-O-isopropylidene-1-(4-phenyl-1H-1,2,3-triazol-1-yl)-7-O-trityl-D-allo-heptitol

Base Information

Chemical Name:3,6-anhydro-1,2-dideoxy-4,5-O-isopropylidene-1-(4-phenyl-1H-1,2,3-triazol-1-yl)-7-O-trityl-D-allo-heptitol
CAS No.:937251-04-2
Molecular Formula:C₃₇H₃₇N₃O₄
Molecular Weight:587.718
Hs Code.:

Synonyms:3,6-anhydro-1,2-dideoxy-4,5-O-isopropylidene-1-(4-phenyl-1H-1,2,3-triazol-1-yl)-7-O-trityl-D-allo-heptitol

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Chemical Property of 3,6-anhydro-1,2-dideoxy-4,5-O-isopropylidene-1-(4-phenyl-1H-1,2,3-triazol-1-yl)-7-O-trityl-D-allo-heptitol

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Technology Process of 3,6-anhydro-1,2-dideoxy-4,5-O-isopropylidene-1-(4-phenyl-1H-1,2,3-triazol-1-yl)-7-O-trityl-D-allo-heptitol

There total 4 articles about 3,6-anhydro-1,2-dideoxy-4,5-O-isopropylidene-1-(4-phenyl-1H-1,2,3-triazol-1-yl)-7-O-trityl-D-allo-heptitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 937251-03-1
3,6-anhydro-1-azido-1,2-dideoxy-4,5-O-isopropylidene-7-O-trityl-D-allo-heptitol

: 536-74-3
phenylacetylene

: 937251-04-2
3,6-anhydro-1,2-dideoxy-4,5-O-isopropylidene-1-(4-phenyl-1H-1,2,3-triazol-1-yl)-7-O-trityl-D-allo-heptitol

: 937251-05-3
3,6-anhydro-1,2-dideoxy-4,5-O-isopropylidene-1-(5-phenyl-1H-1,2,3-triazol-1-yl)-7-O-trityl-D-allo-heptitol

Guidance literature:: In toluene; at 80 ℃; for 24h;
DOI:10.1016/j.bmcl.2007.02.017

Reference yield:

: 937251-02-0
3,6-anhydro-2-deoxy-4,5-O-isopropylidene-1-O-(methylsulfonyl)-7-O-trityl-D-allo-heptitol

: 937251-04-2
3,6-anhydro-1,2-dideoxy-4,5-O-isopropylidene-1-(4-phenyl-1H-1,2,3-triazol-1-yl)-7-O-trityl-D-allo-heptitol

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / NaN₃ / dimethylformamide / 7 h / 100 °C

2: 38 percent / toluene / 24 h / 80 °C

With sodium azide; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2007.02.017

Reference yield:

: 56752-57-9
methyl 3,6-anhydro-2-deoxy-4,5-O-isopropylidene-7-O-trityl-D-allo-heptanoate

: 937251-04-2
3,6-anhydro-1,2-dideoxy-4,5-O-isopropylidene-1-(4-phenyl-1H-1,2,3-triazol-1-yl)-7-O-trityl-D-allo-heptitol

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / LiAlH₄ / diethyl ether / 18 h / 20 °C

2: 74 percent / DMAP; pyridine / 2 h / 20 °C

3: 83 percent / NaN₃ / dimethylformamide / 7 h / 100 °C

4: 38 percent / toluene / 24 h / 80 °C

With pyridine; dmap; lithium aluminium tetrahydride; sodium azide; In diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2007.02.017