937251-02-0Relevant articles and documents
Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors
Goeminne,McNaughton,Bal,Surpateanu,Van Der Veken,De Prol,Versees,Steyaert,Haemers,Augustyns
, p. 315 - 326 (2008/09/18)
Nucleoside hydrolase (NH) is a key enzyme in the purine salvage pathway. The purine specificity of the IAG-NH from Trypanosoma vivax is at least in part due to cation-π-stacking interactions. Guanidinium ions can be involved in cation-π-stacking interactions, therefore a series of guanidino-alkyl-ribitol derivatives were synthesized in order to examine the binding affinity of these compounds towards the target enzyme. The compounds show moderate to good inhibiting activity towards the IAG-NH from T. vivax.
1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors
Goeminne,McNaughton,Bal,Surpateanu,Van der Veken,De Prol,Versees,Steyaert,Apers,Haemers,Augustyns
, p. 2523 - 2526 (2008/02/05)
A range of novel 1,2,3-triazolylalkylribitol derivatives were synthesized and evaluated as nucleoside hydrolase inhibitors. The most active compound (11a) has low micromolar potency and is structurally diverse from previously reported nucleoside hydrolase