1-(hydroxymethyl)-3,4,5-tri{2-[2-(2-ethoxyethoxy)ethoxy]ethoxy}benzene

Base Information

• Chemical Name: 1-(hydroxymethyl)-3,4,5-tri{2-[2-(2-ethoxyethoxy)ethoxy]ethoxy}benzene
• CAS No.: 1096159-35-1
• Molecular Formula: C₃₁H₅₆O₁₃
• Molecular Weight: 636.778
• Mol file: 1096159-35-1.mol

Synonyms:1-(hydroxymethyl)-3,4,5-tri{2-[2-(2-ethoxyethoxy)ethoxy]ethoxy}benzene

Chemical Property of 1-(hydroxymethyl)-3,4,5-tri{2-[2-(2-ethoxyethoxy)ethoxy]ethoxy}benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(hydroxymethyl)-3,4,5-tri{2-[2-(2-ethoxyethoxy)ethoxy]ethoxy}benzene

There total 5 articles about 1-(hydroxymethyl)-3,4,5-tri{2-[2-(2-ethoxyethoxy)ethoxy]ethoxy}benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 3,4,5-Tris(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)benzoate (1096159-34-0) → 1-(hydroxymethyl)-3,4,5-tri{2-[2-(2-ethoxyethoxy)ethoxy]ethoxy}benzene (1096159-35-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -5 - 25 ℃; Inert atmosphere;

DOI:10.1039/b811464a

Reference yield:

ethyl-3,4,5-tri{2-[2-(2-ethoxyethoxy)ethoxy]ethoxy}benzoate → 1-(hydroxymethyl)-3,4,5-tri{2-[2-(2-ethoxyethoxy)ethoxy]ethoxy}benzene (1096159-35-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere; Reflux;

DOI:10.1002/anie.201812465

Reference yield:

2-(2-(2-ethoxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate (62921-75-9) → 1-(hydroxymethyl)-3,4,5-tri{2-[2-(2-ethoxyethoxy)ethoxy]ethoxy}benzene (1096159-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 24 h / 80 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / -5 - 25 °C

With lithium aluminium tetrahydride; potassium carbonate; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2013.09.019

upstream raw materials:

methyl 3,4,5-Tris(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)benzoate

2-(2-(2-ethoxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate

monoethyl ether of triethylene glycol

2-[2-(2-ethoxyethoxy)ethoxy]ethyl chloride

Downstream raw materials:

3,4,5-tris(2-(2-(2-(3,4,5-tris(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)benzyl-oxy)ethoxy)ethoxy)ethoxy)benzoic acid

3,4,5-tris(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)benzyl methacrylate

3,4,5-tris(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)benzyl chloride

2-(8-(3,4,5-tris(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)benzyloxy)octyloxy)tetrahydro-2H-pyran