methanesulfonate of 8-chloro-3,4-dihydro-1-(2-chlorophenyl)-5H-2-benzazepin-5-one

Base Information

Chemical Name:methanesulfonate of 8-chloro-3,4-dihydro-1-(2-chlorophenyl)-5H-2-benzazepin-5-one
CAS No.:76049-71-3
Molecular Formula:CH₄O₃S*C₁₆H₁₁Cl₂NO
Molecular Weight:400.282
Hs Code.:

Synonyms:methanesulfonate of 8-chloro-3,4-dihydro-1-(2-chlorophenyl)-5H-2-benzazepin-5-one

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Chemical Property of methanesulfonate of 8-chloro-3,4-dihydro-1-(2-chlorophenyl)-5H-2-benzazepin-5-one

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Technology Process of methanesulfonate of 8-chloro-3,4-dihydro-1-(2-chlorophenyl)-5H-2-benzazepin-5-one

There total 5 articles about methanesulfonate of 8-chloro-3,4-dihydro-1-(2-chlorophenyl)-5H-2-benzazepin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 76049-64-4
3-amino-1-[2-(2-chlorobenzoyl)-4-chlorophenyl]-propyne

: 76049-71-3
methanesulfonate of 8-chloro-3,4-dihydro-1-(2-chlorophenyl)-5H-2-benzazepin-5-one

Guidance literature:: With ammonium hydroxide; sulfuric acid; In dichloromethane; isopropyl alcohol; at 0 ℃; for 4h;
DOI:10.1021/jo00133a040

Reference yield: 20.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 78367-91-6
2-<<4-chloro-2-(2-chlorobenzoyl)phenyl>-3-oxopropyl>-1H-isoindole-1,3(2H)-dione

: 76049-71-3
methanesulfonate of 8-chloro-3,4-dihydro-1-(2-chlorophenyl)-5H-2-benzazepin-5-one

Guidance literature:: With methylamine; In methanol; ethanol; dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jo00133a040

Reference yield:

: 76049-54-2
N-<<4-chloro-2-(2-chlorobenzoyl)phenyl>-3-propynyl>isoindole-1,3(2H)-dione

: 76049-71-3
methanesulfonate of 8-chloro-3,4-dihydro-1-(2-chlorophenyl)-5H-2-benzazepin-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / 40percent aq. methylamine / aq. ethanol / 2 h / Ambient temperature

2: 42 percent / 1.) conc. sulfuric acid, 2.) ammonium hydroxide / CH₂Cl₂; propan-2-ol / 4 h / 0 °C

With ammonium hydroxide; sulfuric acid; methylamine; In ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jo00133a040